SML3252

SF3B1 Protein Degrader

≥95% (HPLC)

• Sinónimos: 2-((4-chlorophenyl)amino)-N-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)thiazole-4-carboxamide, O4I2-based PROTAC^® degrader
• Fórmula empírica (notación de Hill): C₂₉H₂₉ClN₆O₅S
• Peso molecular: 609.10
• UNSPSC Code: 12352202
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: powder
• storage condition: under inert gas
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• Storage temp.: 2-8°C
• SMILES string: O=C1N(C(C2=C1C=CC=C2NCCCCCCNC(C3=CSC(NC4=CC=C(C=C4)Cl)=N3)=O)=O)C5CCC(NC5=O)=O
• Inchi Key: UWYLVQJEOCYCEW-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

Cell permeable degrader of splicing factor 3B1 (SF3B1)

SF3B1 Protein degrader (reported as "PROTAC-O4I2" in Gama-Brambila et al.) is a cell permeable degrader of splicing factor 3B1 (SF3B1) containing an SF3B1 activator O4I2 connected to the ligand of the cereblon ubiquitin ligase thalidomide. PROTAC-O4I2 selectively degrades SF3B1 in cells. It induces apoptosis of tumor cells and extends survival in Drosophila intestinal tumor model.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable