SML3207

MB05032

≥98% (HPLC)

• Sinónimos: 2-Amino-5-isobutyl-4-[5-phosphono-2-furanyl]thiazole, 5-[2-Amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]phosphonic acid, CS-917 active drug, MB 05032, MB-05032, MB-06322 active drug, MB06322 active drug, [5-[2-Amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
• Fórmula empírica (notación de Hill): C₁₁H₁₅N₂O₄PS
• Número de CAS: 261365-11-1
• Peso molecular: 302.29
• Número MDL: MFCD14584901
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to beige
• solubilidad: DMSO: 2 mg/mL, clear (warmed)
• temp. de almacenamiento: −20°C
• cadena SMILES: [P](=O)(O)(O)c1[o]c(cc1)c2nc([s]c2CC(C)C)N
• InChI: 1S/C11H15N2O4PS/c1-6(2)5-8-10(13-11(12)19-8)7-3-4-9(17-7)18(14,15)16/h3-4,6H,5H2,1-2H3,(H2,12,13)(H2,14,15,16)
• Clave InChI: XJMYIJPPDSZOPN-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

AMP site-targeting, potent and selective fructose-1,6-bisphosphatase (FBPase) inhibitor that suppresses cellular gluconeogenesis (GNG).

MB05032 is an AMP site-targeting, potent and selective fructose-1,6-bisphosphatase (FBPase) inhibitor (rec hum liver FBPase IC50 = 16 nM, purified hum muscle/rat liver FBPase IC50 = 29/61 nM) with no potency toward glycogen phosphorylase or AMP-activated protein kinase. MB05032 inhibits cellular (rat/human hepotocytes IC50/glucose gluconeogenesis (GNG) substrate = 7.8 ?M/lactate & pyruvate/rat hepotocytes, 47.5 μM/lactate/human hepotocytes).

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable