SML2854

Polmacoxib

≥98% (HPLC)

• Sinónimos: 4-[3-(3-fluorophenyl)-4,5-dihydro-5,5-dimethyl-4-oxo-2-furanyl]-benzenesulfonamide, CG100649
• Fórmula empírica (notación de Hill): C₁₈H₁₆FNO₄S
• Número CAS: 301692-76-2
• Peso molecular: 361.39
• UNSPSC Code: 51111800
• NACRES: NA.77
• MDL number: MFCD22570958
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: NS(C1=CC=C(C=C1)C(OC2(C)C)=C(C2=O)C3=CC=CC(F)=C3)(=O)=O
• InChI: 1S/C18H16FNO4S/c1-18(2)17(21)15(12-4-3-5-13(19)10-12)16(24-18)11-6-8-14(9-7-11)25(20,22)23/h3-10H,1-2H3,(H2,20,22,23)
• InChI key: IJWPAFMIFNSIGD-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

Inhibitor of cyclooxygenase 2 (COX-2) and the carbonic anhydrases CAI and CAII

Polmacoxib is a nonsteroidal anti-inflammatory drug (NSAID) that acts as an inhibitor of cyclooxygenase 2 (COX-2) and the carbonic anhydrases CAI and CAII. It has also been found to inhibit colorectal adenoma and tumor growth in mouse models.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable