SML2539

NAB-14

≥98% (HPLC)

• Sinónimos: Carbamic acid, N,N-diethyl-, 4-[(1H-indol-7-ylamino)carbonyl]phenyl ester
• Fórmula empírica (notación de Hill): C₂₀H₂₁N₃O₃
• Número CAS: 1237541-73-9
• Peso molecular: 351.40
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• assay: ≥98% (HPLC)
• form: powder
• color: white to gray
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CCN(CC)C(OC(C=C1)=CC=C1C(NC2=C3C(C=CN3)=CC=C2)=O)=O
• InChI: 1S/C20H21N3O3/c1-3-23(4-2)20(25)26-16-10-8-15(9-11-16)19(24)22-17-7-5-6-14-12-13-21-18(14)17/h5-13,21H,3-4H2,1-2H3,(H,22,24)
• InChI key: WCGIKJOMEYPSIP-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

NAB-14 is a negative allosteric modulator (NAM) selective for GluN2C/2D-containing NMDA glutamate receptors. NAB-14 was >800-fold selective for recombinant GluN2C/GluN2D over GluN2A/GluN2B in Xenopus oocytes and exhibited an IC50 value of 580 nM at recombinant GluN1/GluN2D receptors.

Negative allosteric modulator selective for GluN2C/2D-containing NMDA receptors

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable