SML2198

sAJM589

≥98% (HPLC)

• Sinónimos: 5-Hydroxybenzo[a]phenazine, Benzo[a]phenazin-5-ol
• Fórmula empírica (notación de Hill): C₁₆H₁₀N₂O
• Número de CAS: 2089-82-9
• Peso molecular: 246.26
• Número MDL: MFCD00437759
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: yellow to orange
• solubilidad: DMSO: 2 mg/mL, clear (warmed)
• temp. de almacenamiento: −20°C
• cadena SMILES: OC1=C2C(C=CC=C2)=C3C(N=C(C=CC=C4)C4=N3)=C1
• Clave InChI: WZBDRAAGHRCRKM-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

Myc inhibitor that disrupts the Myc-Max heterodimer

sAJM589 is a Myc inhibitor that disrupts the Myc-Max heterodimer with an IC50 value of 1.8 μM. sAJM589 was shown to suppress cellular proliferation in a variety of MYC-dependent cancer cell line including strong inhibition of Burkitt lymphoma Raji cell line growth. The mechanism of action of sAJM589 is thought to involve increased ubiquitination of Myc by inhibition of Max binding to Myc, leading to proteasome-mediated degradation.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable