SML1926

GAT211

≥98% (HPLC)

• Sinónimos: 3-(2-Nitro-1-phenylethyl)-2-phenyl-1H-indole
• Fórmula empírica (notación de Hill): C₂₂H₁₈N₂O₂
• Número de CAS: 102704-40-5
• Peso molecular: 342.39
• MDL number: MFCD02165420
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=[N+]([O-])CC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3)NC4=CC=CC=C42
• InChI: 1S/C22H18N2O2/c25-24(26)15-19(16-9-3-1-4-10-16)21-18-13-7-8-14-20(18)23-22(21)17-11-5-2-6-12-17/h1-14,19,23H,15H2
• InChI key: OHZDCJJHWPHZJD-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

GAT211 is a positive allosteric modulator (PAM) of cannabinoid CB1 receptor signaling. GAT211 was found to amplify the therapeutic effect of endocannabinoids without the negative side effects of psychoactivity or tolerance. GAT211 caused a CB1-dependent suppression of paclitaxel-induced mechanical and cold allodynia with no sign of tolerance over 19 days of administration.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable