SML1760

BAM15

≥98% (HPLC), powder, mitochondrial protonophore uncoupler

• Sinónimos: BAM 15, N5,N6-bis(2-Fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
• Fórmula empírica (notación de Hill): C₁₆H₁₀F₂N₆O
• Número CAS: 210302-17-3
• Peso molecular: 340.29
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00373912
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Nombre del producto: BAM15, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: FC(C=CC=C1)=C1NC2=NC3=NON=C3N=C2NC4=CC=CC=C4F
• InChI: 1S/C16H10F2N6O/c17-9-5-1-3-7-11(9)19-13-14(20-12-8-4-2-6-10(12)18)22-16-15(21-13)23-25-24-16/h1-8H,(H,19,21,23)(H,20,22,24)
• InChI key: OEGJBRZAJRPPHL-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

BAM15 is a cell penetrant and potent uncoupler of oxidative phosphorylation in mitochondria that that does not depolarizes the plasma membrane. BAM15 protects mice from acute renal ischemic-reperfusion injury.

BAM15 is a cell penetrant and potent uncoupler of oxidative phosphorylation in mitochondria.

BAM15 increases mitochondrial respiration rate and is also found to be less cytotoxic compared to other protonophore uncouplers such as carbonyl cyanide p-trifluoromethoxyphenylhydrazone. Hindered oncogenic MAPK (mitogen-activated protein kinase ) signaling leads to BAM15 induced mitochondrial apoptotic pathway activation.

Información de seguridad

• hcodes: H413
• pcodes: P273 - P501
• Hazard Classifications: Aquatic Chronic 4
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable