SML1689

Eupatilin

from (Isolated from Artemisia sp.), ≥98% (HPLC), powder, lipophilic flavonoid

• Sinónimos: 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one, 5,7-Dihydroxy-3′,4′,6-trimethoxyflavone, NSC 122413
• Fórmula empírica (notación de Hill): C₁₈H₁₆O₇
• Número CAS: 22368-21-4
• Peso molecular: 344.32
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826018
• NACRES: NA.77
• MDL number: MFCD13194819
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated, protect from light

Propiedades

• Nombre del producto: Eupatilin, ≥98% (HPLC)
• biological source: (Isolated from Artemisia sp.)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated, protect from light
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=CC(O)=C(OC)C(O)=C31
• InChI: 1S/C18H16O7/c1-22-12-5-4-9(6-14(12)23-2)13-7-10(19)16-15(25-13)8-11(20)18(24-3)17(16)21/h4-8,20-21H,1-3H3
• InChI key: DRRWBCNQOKKKOL-UHFFFAOYSA-N

Descripción

Application

Eupatilin has been used to investigate its inhibitory effects on intracranial hemorrhage (ICH)-induced inflammation and its anti-inflammatory mechanisms in mouse BV2 cells, in vitro. It has also been used as a standard for its quantitative estimation in Artemisia extracts by microcolumn high performance liquid chromatography with diode array (HPLC-DAD) assay.

Biochem/physiol Actions

Eupatilin is a flavone with anti-oxidative, anti-inflammatory, and anti-cancer properties.

Flavone with anti-oxidative, anti-inflammatory, and anti-cancer properties

Eupatilin is an important constituent in the leaves of Artemisia argyi and also an active component of DA-9601. It exhibits anti-apoptotic effects. Eupatilin provides protection against tumor necrosis factor α (TNF-α)-mediated inflammation in human umbilical vein endothelial cells. It is used in the treatment of gastritis and peptic ulcers. Eupatilin safeguards gastric epithelial cells from oxidative damage and smooth muscle cells from indomethacin-induced cell damage. Eupatilin lowers bile acid-stimulated hepatocyte apoptosis.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable