SML1637

Hexaminolevulinate hydrochloride

≥98% (HPLC)

• Sinónimos: 5-Aminolevulinic acid hexyl ester HAL hydrochloride, 5-Aminolevulinic acid hexyl ester hydrochloride, HAL, Hexvix, Hexyl 5-aminolevulinate hydrochloride, P 1206, n-Hexyl 5-aminolevulinate hydrochloride
• Fórmula empírica (notación de Hill): C₁₁H₂₁NO₃ · HCl
• Número de CAS: 140898-91-5
• Peso molecular: 251.75
• Número MDL: MFCD03695491
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825978
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated
• color: white to beige
• solubilidad: H₂O: 20 mg/mL, clear
• temp. de almacenamiento: room temp
• cadena SMILES: CCCCCCOC(CCC(CN)=O)=O.[H]Cl
• InChI: 1S/C11H21NO3.ClH/c1-2-3-4-5-8-15-11(14)7-6-10(13)9-12;/h2-9,12H2,1H3;1H
• Clave InChI: LZYXPFZBAZTOCH-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

Hexaminolevulinate (HAL) hydrochloride is a hexyl ester of 5-Aminolevulinic acid (ALA), a precursor to porphyrins including the photosensitizer protoporphyrin IX (PPIX). Hexaminolevulinate is more lipophilic than ALA, and is 50–100 times more efficient than ALA at inducing PpIX, which accumulates preferentially in neoplastic cells. Hexaminolevulinate administration followed by light activation has been used for fluorescence cystoscopy to enhance detection of bladder cancer, in particular carcinoma in situ (CIS). Hexaminolevulinate is also being studied for use in cancer photodynamic therapy. Hexaminolevulinate followed by irradiation produced DNA oxidative damage and apoptosis.

Hexaminolevulinate is a hexyl ester of 5-Aminolevulinic acid; imaging agen for fluorescence cyctoscopy; photosensitizer.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3