SML1528

Iloperidone

≥98% (HPLC)

• Sinónimos: 1-[4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone, Zomaril
• Fórmula empírica (notación de Hill): C₂₄H₂₇FN₂O₄
• Número CAS: 133454-47-4
• Peso molecular: 426.48
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825945
• NACRES: NA.77
• MDL number: MFCD00866688
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear
• storage temp.: −20°C
• SMILES string: Fc1cc2[o]nc(c2cc1)C3CCN(CC3)CCCOc4c(cc(cc4)C(=O)C)OC
• InChI: 1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3
• InChI key: XMXHEBAFVSFQEX-UHFFFAOYSA-N
• Gene Information: human ... DRD2(1813), HTR2A(3356)

Descripción

Biochem/physiol Actions

Iloperidone is an atypical antipsychotic, a combined dopamine (D2) and serotonin (5HT2) receptor antagonist.

Iloperidone is an atypical antipsychotic, a combined dopamine (D2) and serotonin (5HT2) receptor antagonist. Iloperidone targets a selective set of dopamine, serotonin and also norepinephrine receptor subtypes. Like similar atypical antipsychotics, Iloperidone has higher affinity for the 5-HT2A receptor (Ki < 10 nM) than for the D2 receptor (Ki = 10–100) nM). Iloperidone has high affinity for dopamine D3 (Ki < 10 nM) and lower affinity for other serotonin or dopamine subtypes. Unlike most atypical antipsychotics, Iloperidone also has high affinity for norepinephrine alpha1 receptors (Ki < 10 nM) which may contribute to the drug′s efficacy on mood and cognition.

Información de seguridad

• Pictogramas: GHS06
• Palabra de advertencia: Danger
• Códigos de peligro: H301,H413
• Indicaciones de precaución: P264 - P270 - P273 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 4
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable