SML1497

Canrenone

≥97% (HPLC), mineralocorticoid inhibitor, powder

• Sinónimos: (17α)-17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid γ-lactone, NSC 261713
• Fórmula empírica (notación de Hill): C₂₂H₂₈O₃
• Número CAS: 976-71-6
• Peso molecular: 340.46
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825921
• NACRES: NA.77
• MDL number: MFCD00071735
• Assay: ≥97% (HPLC)
• Form: powder

Propiedades

• Nombre del producto: Canrenone, ≥97% (HPLC)
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• optical activity: [α]/D +17 to +24°, c = 1 in chloroform-d
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: room temp
• SMILES string: C[C@@]12C(C=C[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]45OC(CC5)=O)=CC(CC1)=O
• InChI: 1S/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1
• InChI key: UJVLDDZCTMKXJK-WNHSNXHDSA-N
• Gene Information: human ... NR3C2(4306)

Descripción

Biochem/physiol Actions

Canrenone is a mineralocorticoid (aldosterone) inhibitor.

Canrenone is a mineralocorticoid (aldosterone) inhibitor. Aldosterone is known to be involved in hypertension, kidney disease, atherosclerosis, and heart failure. Blockade of the aldosterone receptor has been shown to improve cardiovascular function. In congestive heart failure, aldosterone antagonists are used in addition to other drugs for additive diuretic effect, which reduces edema and the cardiac workload.
Canrenone is an active metabolite of spironolactone with potassium-sparing diuretic activity. Canrenone specifically antagonizes aldosterone at the mineralocorticoid receptor in the kidneys, thereby increasing sodium excretion and inhibiting potassium excretion. It is known to reduce the inflammatory reaction influenced by aldosterone.

Información de seguridad

• Pictogramas: GHS08,GHS09
• Palabra de advertencia: Warning
• Códigos de peligro: H351,H411
• Indicaciones de precaución: P202 - P273 - P280 - P308 + P313 - P391 - P405
• Hazard Classifications: Aquatic Chronic 2 - Carc. 2 Oral
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable