SML1216

Ravuconazole

≥97% (NMR), sterol biosynthesis inhibitor, powder

• Sinónimos: 4-[2-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile, BMS-207147, ER-30346
• Fórmula empírica (notación de Hill): C₂₂H₁₇F₂N₅OS
• Número CAS: 182760-06-1
• Peso molecular: 437.47
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥97% (NMR)
• Form: powder

Propiedades

• Nombre del producto: Ravuconazole, ≥97% (NMR)
• Quality Segment: 100
• assay: ≥97% (NMR)
• form: powder
• optical activity: [α]/D -27 to -33°, c = 1 in methanol
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: Fc1c(ccc(c1)F)[C@](O)([C@@H](C)c3[s]cc(n3)c4ccc(cc4)C#N)C[n]2ncnc2
• InChI: 1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-7-6-17(23)8-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1
• InChI key: OPAHEYNNJWPQPX-RCDICMHDSA-N

Descripción

Biochem/physiol Actions

Ravuconazole (BMS-207147) is a potent and broad spectrum triazole antifungal. Ravuconazole is an inhibitor of sterol biosynthesis by inhibition of cytochrome P450 14α-demethylase, an enzyme in the sterol biosynthesis pathway that leads from lanosterol to ergosterol.

Ravuconazole is a potent and broad spectrum triazole antifungal.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable