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SML0942

GSK2193874

Name: GSK2193874
Brand: SIGMA

≥98% (HPLC), TRPV4 ion channel antagonist, powder

Sinónimos:

3-([1,4′-Bipiperidin]-1′-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

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Fórmula empírica (notación de Hill):

C₃₇H₃₈BrF₃N₄O

Número CAS:

1336960-13-4

Peso molecular:

691.62

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

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Propiedades

Nombre del producto

GSK2193874, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >5 mg/mL, clear

storage temp.

room temp

SMILES string

FC(F)(F)c1cc(ccc1)c2nc3c(c(c2CN6CCC(CC6)N7CCCCC7)C(=O)NC5(CC5)c4ccccc4)ccc(c3)Br

InChI

1S/C37H38BrF3N4O/c38-28-12-13-30-32(23-28)42-34(25-8-7-11-27(22-25)37(39,40)41)31(24-44-20-14-29(15-21-44)45-18-5-2-6-19-45)33(30)35(46)43-36(16-17-36)26-9-3-1-4-10-26/h1,3-4,7-13,22-23,29H,2,5-6,14-21,24H2,(H,43,46)

InChI key

UIVOZBSCHXCGPS-UHFFFAOYSA-N

Descripción

Application

GSK2193874 has been used as a transient receptor potential vanilloid 4 (TRPV4) antagonist:

to study its effects on GSK101-induced colon contractions in mice[1]
to study its effects on murine compact bone-derived osteoblasts(CB-OB)[2]
to study its effects on lung injury post-lipopolysaccharide (LPS) in mice[3]

Biochem/physiol Actions

GSK2193874 is a very potent, specific antagonist of TRPV4 ion channels (IC₅₀= 50 nM). Lung edema caused by high pulmonary venous pressure (PVP) is driven by TRPV4 activity. GSK2193874 blocks TRPV4-mediated calcium influx in cells expressing native and recombinant TRPV4, and inhibits vascular permeability and lung edema in isolated rodent and canine lungs subjected to high PVP. The compound also resolves pulmonary edema in murine myocardial infarction model.

GSK2193874 is a very potent, specific antagonist of TRPV4.

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Este artículo	S7326	S5192	SML0481
Sigma-Aldrich SML0942 GSK2193874	Sigma-Aldrich S7326 SB 657510	Sigma-Aldrich S5192 SB 222200	Sigma-Aldrich SML0481 Qc1
form powder	form powder	form solid	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. room temp	storage temp. room temp	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: >5 mg/mL, clear	solubility DMSO: ≥30 mg/mL	solubility DMSO: soluble ~28 mg/mL, H₂O: insoluble	solubility DMSO: 5 mg/mL (clear solution, warmed)
color white to beige	color white to off-white	color light yellow	color white to beige

pictograms

GHS06

signalword

Danger

hcodes

H301,H315,H319,H335

pcodes

P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c