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Merck

SML0931

Sigma-Aldrich

Carbimazole

≥98% (HPLC)

Sinónimos:

1-Ethoxycarbonyl-3-methyl-2-thio-4-imidazoline, 1-Methyl-3-carbethoxy-2-thioglyoxalone, 2,3-Dihydro-3-methyl-2-thioxo-1H-imidazole-1-carboxylic acid ethyl ester, Athyromazole, Carbethoxymethimazole, Carbimazol, Ethyl 3-methyl-2-thioimidazoline-1-carboxylate

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About This Item

Fórmula empírica (notación de Hill):
C7H10N2O2S
Número de CAS:
Peso molecular:
186.23
Número CE:
Código UNSPSC:
12352200
NACRES:
NA.77

Ensayo

≥98% (HPLC)

Formulario

powder

color

white to beige

solubilidad

DMSO: 5 mg/mL, clear (warmed)

temp. de almacenamiento

2-8°C

cadena SMILES

S=[c]1[n](cc[n]1C(=O)OCC)C

InChI

1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H,3H2,1-2H3

Clave InChI

CFOYWRHIYXMDOT-UHFFFAOYSA-N

Acciones bioquímicas o fisiológicas

Carbimazole is a pro-drug of methimazole that is an inhibitor of thyroid enzyme thyroperoxidase.
Carbimazole is a pro-drug of methimazole that is an inhibitor of thyroid enzyme thyroperoxidase. Carbimazole is used to treat hyperthyroidism. Also, carbimazole induces phosphorylation of eukaryotic elongation factor eEF2.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Dinesh Kumar Dhanwal et al.
The Journal of the Association of Physicians of India, 59, 561-562 (2012-02-18)
Hyperthyroidism is associated with bone loss, which is reversible after treatment. The extent of reversibility of loss of bone mass density (BMD) in hyperthyroid patients after treatment especially at forearm is not clear. Therefore, the present study was conducted to
Dhanya Muralidharan et al.
Oral surgery, oral medicine, oral pathology and oral radiology, 115(5), 617-623 (2013-03-05)
Animal studies have shown thyroid dysfunction affects salivary gland functioning, however conclusive human studies are lacking. We sought to assess the qualitative and quantitative changes in saliva among subjects with thyroid dysfunction prior to and following treatment. A longitudinal observational
Sarah M A Caney
Journal of feline medicine and surgery, 15(6), 494-502 (2013-04-18)
Hyperthyroidism is the most common feline endocrinopathy. Treatment options comprise anti-thyroid medication, iodine-restricted diet, surgical thyroidectomy and radioiodine. One hundred and eleven owners of hyperthyroid cats completed a detailed survey asking about their experiences and views on the management of
Which antithyroid drug regimen in paediatric Graves' disease?
Daniel Schenk et al.
Clinical endocrinology, 77(6), 806-807 (2012-07-24)
Thomas A Mavrakanas et al.
Renal failure, 35(3), 414-417 (2013-01-25)
Anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis is a rare complication of antithyroid drug use that was first described with propylthiouracil. We describe an ANCA-associated rapidly progressive glomerulonephritis in a patient treated with carbimazole during 6 months for Graves disease that resulted in

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