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SML0584

Sigma-Aldrich

NNGH

≥98% (HPLC)

Sinónimos:

BML-205, N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid

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About This Item

Fórmula empírica (notación de Hill):
C13H20N2O5S
Número de CAS:
161314-17-6
Peso molecular:
316.37
MDL number:
MFCD02179370
UNSPSC Code:
12352200
PubChem Substance ID:
329825565
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 15 mg/mL, clear

storage temp.

2-8°C

SMILES string

COc1ccc(cc1)S(=O)(=O)N(CC(C)C)CC(=O)NO

InChI

1S/C13H20N2O5S/c1-10(2)8-15(9-13(16)14-17)21(18,19)12-6-4-11(20-3)5-7-12/h4-7,10,17H,8-9H2,1-3H3,(H,14,16)

InChI key

JIRXORZYIXSWOB-UHFFFAOYSA-N

Biochem/physiol Actions

NNGH is a potent and cell-permeable inhibitor of matrix metalloproteinase 3 (MMP-3,stromelysin 1, progelatinase). NNGH has been used to inhibit MMP-3 in a variety of studies. Inhibition of MMP-3 with NNGH significantly suppressed the expression of iNOS and pro-inflammatory cytokines and the activities of NF-KB, AP-1, and MAPK in LPS-stimulated microglia, suggesting a role for MMP-3 in neuroinflammation.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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