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SML0341

Importazole

Name: Importazole
Brand: SIGMA

≥98% (HPLC), importin-β transport receptor inhibitor, powder

Sinónimos:

N-(1-Phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine

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Fórmula empírica (notación de Hill):

C₂₀H₂₂N₄

Número CAS:

662163-81-7

Peso molecular:

318.42

UNSPSC Code:

12352200

PubChem Substance ID:

329825346

NACRES:

NA.77

MDL number:

MFCD04077630

Assay:

≥98% (HPLC)

Form:

powder

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Propiedades

Nombre del producto

Importazole, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >5 mg/mL

storage temp.

2-8°C

SMILES string

CC(C1=CC=CC=C1)NC2=NC(N3CCCC3)=NC4=C2C=CC=C4

InChI

1S/C20H22N4/c1-15(16-9-3-2-4-10-16)21-19-17-11-5-6-12-18(17)22-20(23-19)24-13-7-8-14-24/h2-6,9-12,15H,7-8,13-14H2,1H3,(H,21,22,23)

InChI key

HKGJEZIGDHFJFL-UHFFFAOYSA-N

Descripción

Application

Importazole has been used:

to inhibit importin-β and to elucidate the mechanism of enhanced nuclear localization of heat shock protein 70 (HSP70) by vaccinia-related kinase 3 (VRK3)
to treat COS?7 cells transfected with the expressing vectors of WT HNF4α , S78A, and S78D to study its effect
as a KPNB inhibitor to determine whether CREB-regulated co-activator 1 (CRTC1) would be escorted into the nucleus by the classical nuclear localizing sequence (NLS)- dependent machinery
as a functional inhibitor of Importin β in embryo treatment
as an importin inhibitor to treat the transfected H1299 cells to block nuclear translocation of phosphorylated p53-RS

Biochem/physiol Actions

Importazole is an inhibitor of importin-β transport receptors.

Importazole is an inhibitor of importin-β transport receptors. During interphase, the transport receptor importin-β carries cargoes into the nucleus, where RanGTP releases them. Importazole somehow disrupts the importin/RAN interaction. Importazole is selective among other transporters. Compounds are imported into, but not out of, cells.

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Este artículo	401105	PHR2826	1005048
Sigma-Aldrich SML0341 Importazole	Sigma-Aldrich 401105 Importazole	Supelco PHR2826 Acetazolamide Related Compound D	USP 1005048 Acetazolamide Related Compound D
description ≥98% (HPLC)	description A cell-permeable diaminoquinazoline compound that selectively blocks importin-β-mediated nuclear import of NLS bearing cargos in a reversible manner.	description certified reference material, pharmaceutical secondary standard	description United States Pharmacopeia (USP) Reference Standard
form powder	form solid	form solid	form -
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay -	assay -
Quality Level 100	Quality Level 100	Quality Level 300	Quality Level -
storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. -
solubility DMSO: >5 mg/mL	solubility DMSO: 25 mg/mL, clear, colorless	solubility -	solubility -
color white to beige	color white	color -	color -

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Clase de almacenamiento

11 - Combustible Solids

¿Qué está pasando?

WGK 3

Punto de inflamación (°F)

Not applicable

Punto de inflamación (°C)

Not applicable

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