SML0329

Carcinine dihydrochloride

≥98% (HPLC)

• Sinónimos: β-Alanylhistamine dihydrochloride, 3-Amino-N-[2-(1H-imidazol-4-yl)ethyl]propanamide dihydrochloride, Alistin, Beta-Alanylhistamine dihydrochloride
• Fórmula empírica (notación de Hill): C₈H₁₄N₄O · 2HCl
• Número de CAS: 57022-38-5
• Peso molecular: 255.14
• Número MDL: MFCD22200567
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825334
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated
• color: white to beige
• solubilidad: H₂O: >15 mg/mL
• temp. de almacenamiento: −20°C
• cadena SMILES: Cl.Cl.NCCC(=O)NCCc1cnc[nH]1
• InChI: 1S/C8H14N4O.2ClH/c9-3-1-8(13)11-4-2-7-5-10-6-12-7;;/h5-6H,1-4,9H2,(H,10,12)(H,11,13);2*1H
• Clave InChI: ZQTUNIWBUQUKAM-UHFFFAOYSA-N

Descripción

Descripción general

Carcinine, a natural peptide derivative, with a β-alanyl residue and a histamine, carries an imidazole ring. In mammals, carcinine is present in the brain, muscle, intestine and liver tissues.

Aplicación

Carcinine dihydrochloride has been used to study its effects on dopaminergic neuron degeneration.

Acciones bioquímicas o fisiológicas

Carcinine (β-alanyl histamine) is a selective histamine H3 antagonist, 100-1000-fold selective for H3 over H2 and H1, that also functions as an antioxidant and as a chemical chaperone to reduce non-enzymatic glycation of proteins and maintain native folding of proteins.

Carcinine can scavenge a toxic product, called 4-hydroxynonenal (4-HNE), obtained during lipid oxidation. It has a protective role from oxidative damage on photoreceptor cells. Carcinine also exhibits lipid-peroxidase activity.

Carcinine is a selective histamine H3 antagonist; antioxidant.

Características y beneficios

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Pictogramas: GHS05,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H315,H318,H335
• Consejos de prudencia: P280 - P302 + P352 - P305 + P351 + P338 + P310
• Clasificaciones de peligro: Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable