SBR00088

Rilpivirine

≥95% (HPLC), powder

• Sinónimos: 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile, R 278474, TMC 278
• Fórmula empírica (notación de Hill): C₂₂H₁₈N₆
• Número de CAS: 500287-72-9
• Peso molecular: 366.42
• Número MDL: MFCD11046372
• Código UNSPSC: 51101500

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: powder
• color: white to yellow, or beige
• espectro de actividad antibiótica: viruses
• Modo de acción: enzyme | inhibits
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• cadena SMILES: CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)/C=C/C#N
• InChI: 1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+
• Clave InChI: YIBOMRUWOWDFLG-ONEGZZNKSA-N

Descripción

Descripción general

Rilpivirine is an antibiotic which belongs to the class of compounds known as non-nucleoside reverse transcriptase inhibitors (NNRTIs).

Acciones bioquímicas o fisiológicas

Nonnucleoside reverse transcriptase inhibitor (NNRTI); anti-retroviral

Rilpivirine inhibits the activity of the reverse transcriptase enzyme, which is essential for the replication of HIV-1. Specifically, it binds to a specific site on the enzyme and blocks its activity, thereby preventing the conversion of viral RNA into DNA, which is an essential step for the integration of viral DNA into host cells.

Rilpivirine is a next generation nonnucleoside reverse transcriptase inhibitor (NNRTI), It has been shown to be active against many HIV strains with mutations that confer resistance to the first-generation NNRTIs.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable