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Merck
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SAE0149

Sigma-Aldrich

Artificial Saliva for Pharmaceutical Research

Sinónimos:

Artificial Saliva Solution, Saliva Substitute

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About This Item

UNSPSC Code:
51241229
NACRES:
NA.25
En este momento no podemos mostrarle ni los precios ni la disponibilidad

shipped in

wet ice

storage temp.

2-8°C

General description

Artificial saliva helps in gaining a stable environment and standardized procedures for in vitro and in vivo studies in pharmacological and bioengineering fields. This saliva mimics the properties of natural saliva in terms of chemical composition and physical characteristics.[1] Artificial Saliva is formulated according to literature for pharmaceutical research such as studies of drug dissolution and drug delivery through the oral mucosa.

Application

Artificial Saliva for pharmaceutical research has been used:

  • to study the antifungal activity of Candida albicans on the surface of printed denture resin discs[2]
  • as a diluting agent for inactivation of Escherichia coli in droplets are with different ambient humidities[3]
  • to determine the stability of graphene oxide-amoxicillin (GO-AMOX) capsules[4]

Components

Sodium Chloride
Potassium Phosphate Monobasic
Potassium Chloride
Potassium Thiocyanate Urea

Storage and Stability

This is a ready to use formulation that should be stored refrigerated.

Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
MKCW8425
MKCW7224
MKCV5695
MKCV5575
MKCT7253

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J J Pytko-Polonczyk et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 68(6), 807-813 (2018-03-20)
Examination of dental materials and their properties at the initial stage of the digestive process requires the development of conditions that mimic the environment of the oral cavity. One of the main components of this area is saliva, where many
Sol Jeon et al.
Journal of dentistry, 120, 104098-104098 (2022-03-25)
To produce three-dimensionally (3D) printed removable denture bases with antifungal activity using microencapsulation of phytochemicals that inhibit Candida albicans growth. Two types of phytoncide oil extract A and B were micro-encapsulated. The phytoncide-filled microcapsules were mixed with denture base resin
Inactivation of Escherichia coli in droplets at different ambient relative humidities: Effects of phase transition, solute and cell concentrations
Liang Z, et al.
Atmospheric Environment, 119066-119066 (2022)
Anna Trusek et al.
Materials (Basel, Switzerland), 14(12) (2021-07-03)
Graphene oxide (GO) was proposed as an efficient carrier of antibiotics. The model drug, amoxicillin (AMOX), was attached to GO using a peptide linker (Leu-Leu-Gly). GO-AMOX was dispersed in a hydrogel to which the enzyme responsible for releasing AMOX from

Questions

1–3 of 3 Questions  

  1. Is artificial saliva contain glucose?

    1 answer

    1. This product does not contain glucose.

      Helpful?

  2. Hello, is it possible for you to share the composition of this product? I wish you good work.

    1 answer

    1. This product is a buffer solution (pH 6.8) containing 0.126 g/L NaCl, 0.964 g/L KCl, 0.189 g/L KSCN, 0.655 g/L KH2 PO4, and 0.200 g/L urea. This material is formulated according to the literature, please also see the following publication:
      De Caro V, et al. Galantamine Delivery on Buccal Mucosa:Permeation Enhancement and Design of Matrix Tablets. J Bioequiv Availab. 2009;1:127-134. ]

      Helpful?

  3. Could you confirm whether the item is sterile?

    1 answer

    1. No, this product is not sterile.

      Helpful?

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