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SAB5600064

Sigma-Aldrich

Anti-Phospho-akt (ser473) antibody, Rabbit monoclonal

recombinant, expressed in HEK 293 cells, clone RM251, purified immunoglobulin

Sinónimos:

phosphorylation at Ser473

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

recombinante

expressed in HEK 293 cells

Nivel de calidad

100

forma del anticuerpo

purified immunoglobulin

tipo de anticuerpo

primary antibodies

clon

RM251, monoclonal
recombinant monoclonal

Formulario

buffered aqueous glycerol solution

reactividad de especies

human

técnicas

immunoblotting: 1:1000-1:2000
immunohistochemistry: 1:200-1:500

isotipo

IgG

Nº de acceso NCBI

207

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

phosphorylation (pSer473)

Información sobre el gen

human ... AKT1(207)

Descripción general

AKT1 (AKT serine/threonine kinase 1) is also called as v-akt murine thymoma viral oncogene homolog 1 and PKB α (protein kinase B). It is expressed in liver,muscle and adipocytes. AKT1 gene is mapped to human chromosome 14q32. It is a member of AKT family that has an amino-terminal pleckstrin homology (PH) domain, a short α helical linker and a carboxyl-terminal kinase domain.

Especificidad

This antibody reacts to Akt only when phosphorylated at Ser473. There is no cross-reactivity with Akt without phosphorylation at Ser473. This antibody may also react to bovine, mouse or rat Phospho-Akt (Ser473), as predicted by immunogen homology

Inmunógeno

Synthetic peptide corresponding to human Phospho-Akt (Ser473)

Acciones bioquímicas o fisiológicas

AKT1 (AKT serine/threonine kinase 1) controls the survival of cells and anti-apoptotic actions that attack the pathogenesis of several cancers, hence it plays a crucial role in tumorigenesis. In mice, AKT1 is essential for normal development.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
S0302096
P0700583

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Visite la Librería de documentos

Association between single nucleotide polymorphisms in AKT1 and the risk of prostate cancer in the Chinese Han population.
Liu JM, et al.
Genetics and molecular research : GMR, 16(1) (2017)
Claudia Delgadillo-Puga et al.
Nutrients, 15(11) (2023-06-10)
Pecans (Carya illinoinensis) are considered a functional food due to the high content of polyunsaturated fatty acids, dietary fiber and polyphenols. To determine the effect of whole pecans (WP) or a pecan polyphenol (PP) extract on the development of metabolic
Eun-Hui Lee et al.
Scientific reports, 8(1), 9894-9894 (2018-07-04)
Accumulating data have indicated a fundamental role of eosinophils in regulating adipose tissue homeostasis. Here, we performed whole-genome RNA sequencing of the small intestinal tract, which suggested the presence of impaired lipid metabolism in eosinophil-deficient ΔdblGATA mice. ΔdblGATA mice fed
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
Cho H, et al.
The Journal of Biological Chemistry, 276(42), 38349-38352 (2001)
AKT plays a central role in tumorigenesis
Testa JR and Bellacosa A
Proceedings of the National Academy of Sciences of the USA, 98(20), 10983-10985 (2001)
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