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SAB5200077

Sigma-Aldrich

Monoclonal Anti-KCNB1 antibody produced in mouse

clone S89-34, 1 mg/mL, purified immunoglobulin

Sinónimos:

Anti-DRK1PC, Anti-Kcnb1, Anti-Kcr1-1, Anti-Kv2.1, Anti-Kv2.1, S89-34, Anti-Shab

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

mouse

conjugado

unconjugated

forma del anticuerpo

purified immunoglobulin

tipo de anticuerpo

primary antibodies

clon

S89-34, monoclonal

Formulario

buffered aqueous glycerol solution

mol peso

antigen predicted mol wt 105-125 kDa

reactividad de especies

human, mouse, rat

concentración

1 mg/mL

técnicas

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotipo

IgG1

Nº de acceso NCBI

NP_037318

Nº de acceso UniProt

Q14721

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

rat ... Kcnb1(25736)

Descripción general

Potassium voltage-gated channel subfamily B member 1 (KCNB1) is widely distributed in the central nervous system. The gene ID for the protein is 25736.

Especificidad

Detects ~105-125 kDa (varies with cell background due to phosphorylation). No crossreactivity to rat Kv2.2.

Inmunógeno

Synthetic peptide amino acids 837-853 (cytoplamsic Cterminus) of rat KV2.1(HMLPGGGAHGSTRDQSI),Accession Number NP_037318.

Acciones bioquímicas o fisiológicas

Potassium voltage-gated channel subfamily B member 1 (KCNB1) forms microdomains to aid in protein trafficking and has a role in smooth muscle contraction. KCNB1 also takes part in membrane fusion activities. Studies on Chinese hamster ovary (CHO) cells have shown that this protein has a role in apoptosis.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
1012

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Emily Deutsch et al.
Molecular biology of the cell, 23(15), 2917-2929 (2012-06-01)
Voltage-gated K(+) (Kv) channels regulate membrane potential in many cell types. Although the channel surface density and location must be well controlled, little is known about Kv channel delivery and retrieval on the cell surface. The Kv2.1 channel localizes to
Anastasia Grizel et al.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 9(5), 727-739 (2014-09-27)
Voltage-gated potassium Kv2.1 channels are widely distributed in the central nervous system, specifically in neuroendocrine and endocrine cells. Their cytoplasmic C-termini are large and carry out many important functions. Here we provide the first direct structural evidence that each C-terminal
Yasushi Hosoi et al.
Frontiers in molecular neuroscience, 15, 806798-806798 (2022-12-06)
Fetal and infant brains are rich in maternally derived taurine. We previously demonstrated that taurine action regulates the cation-chloride cotransporter activity and the differentiation and radial migration of pyramidal neuron progenitors in the developing neocortex of rodent fetuses. Here we

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