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SAB2501155

Sigma-Aldrich

Anti-TH (C-terminal) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-TYH, tyrosine hydroxylase

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, canine, human

technique(s)

ELISA: suitable
immunohistochemistry: suitable
western blot: suitable

UniProt accession no.

shipped in

dry ice

Storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TH(7054)

General description

Tyrosine hydroxylase (TH) is encoded by the gene mapped to human chromosome 11p15.5. The N-terminal end of the protein plays a vital role in maintaining intracellular stability of the enzyme. Tyrosine hydroxylase is expressed in various tissues such as brain, adrenal medulla, and sympathetically innervated tissues. The enzyme is characterized with a regulatory domain (R), a catalytic domain (C) at N-terminal end, and a coiled-coil domain at the C-terminal end.

Immunogen

Peptide with sequence CVQDELDTLAHAL, from the C Terminus of the protein sequence according to NP_954986.2; NP_000351.2; NP_954987.2.

Biochem/physiol Actions

Tyrosine hydroxylase (TH) specifically catalyzes the hydroxylation of the amino acid L-tyrosine to 3, 4-dihydroxy-L-phenylalanine (L-DOPA). TH is a rate-limiting enzyme involved in the synthesis of catecholamine, which is involved in several brain functions, such as attention, memory, cognition, and emotion. Phosphorylation of the N-terminal portion of tyrosine hydroxylase controls the degradation of this enzyme by the ubiquitin-proteasome pathway. Alteration in the expression of the gene results in the pathogenesis of Parkinson′s disease (PD) and point mutation in the gene coding for TH leads to Segawa′s syndrome.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

A point mutation in the tyrosine hydroxylase gene associated with Segawa's syndrome.
Ludecke B
Human Gene Therapy (1995)
Human tyrosine hydroxylase and insulin genes are contiguous on chromosome 11.
O'Malley KL and Rotwein P
Nucleic Acids Research (1988)
TYROSINE HYDROXYLASE. THE INITIAL STEP IN NOREPINEPHRINE BIOSYNTHESIS.
The Journal of Biological Chemistry (1964)
Tyrosine hydroxylase and regulation of dopamine synthesis.
Archives of Biochemistry and Biophysics (2011)
The function of tyrosine hydroxylase in the normal and Parkinsonian brain.
CNS & Neurological Disorders Drug Targets (2012)

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