R3530

Rifabutin

>98% (HPLC), powder, antibiotic

• Sinónimos: Ansamycin, Ansatipine (Farmitalia), LM-427, Mycobutin (Farmitalia)
• Fórmula empírica (notación de Hill): C₄₆H₆₂N₄O₁₁
• Número CAS: 72559-06-9
• Peso molecular: 847.00
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: >98% (HPLC)
• Form: powder
• Storage condition: protect from light

Propiedades

• Nombre del producto: Rifabutin, >98% (HPLC), powder
• assay: >98% (HPLC)
• form: powder
• storage condition: protect from light
• solubility: DMSO: >5 mg/mL
• antibiotic activity spectrum: neoplastics
• mode of action: enzyme | inhibits
• originator: Johnson & Johnson
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: [N+H]1(CCC2(NC3=C4NC(=O)\C(=C/C=C/[C@@H]([C@@H]([C@H]([C@H]([C@H]([C@@H]([C@@H]([C@H](\C=C\O[C@]5(Oc6c(c(c(c(c6C)[O-])C4=O)C3=N2)C5=O)C)OC)C)OC(=O)C)C)O)C)O)C)\C)CC1)CC(C)C
• InChI: 1S/C46H62N4O11/c1-22(2)21-50-18-16-46(17-19-50)48-34-31-32-39(54)28(8)42-33(31)43(56)45(10,61-42)59-20-15-30(58-11)25(5)41(60-29(9)51)27(7)38(53)26(6)37(52)23(3)13-12-14-24(4)44(57)47-36(40(32)55)35(34)49-46/h12-15,20,22-23,25-27,30,37-38,41,49,52-54H,16-19,21H2,1-11H3,(H,47,57)/b13-12+,20-15+,24-14-/t23-,25+,26+,27+,30-,37-,38+,41+,45-/m0/s1
• InChI key: ATEBXHFBFRCZMA-VXTBVIBXSA-N

Descripción

Biochem/physiol Actions

Rifabutin is an antibiotic; antitumor.

Rifabutin is an antibiotic; antitumor. Rifabutin interferes with HSP-90 molecular chaperone, enhances ubiquitination and protein degradation, and inactivates bacterial RNA polymerase.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)