R101

Ranitidine hydrochloride

H2 histamine receptor antagonist;, solid

• Fórmula empírica (notación de Hill): C₁₃H₂₂N₄O₃S · HCl
• Número CAS: 66357-59-3
• Peso molecular: 350.86
• NACRES: NA.77
• PubChem Substance ID: 24277803
• UNSPSC Code: 12352200
• EC Number: 266-333-0
• MDL number: MFCD00069339
• Form: solid

Propiedades

• Nombre del producto: Ranitidine hydrochloride, solid
• form: solid
• Quality Segment: 200
• color: tan
• solubility: H₂O: 1.8 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 7.0 mg/mL
• originator: GlaxoSmithKline
• SMILES string: Cl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O
• InChI: 1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;
• InChI key: GGWBHVILAJZWKJ-CHHCPSLASA-N
• Gene Information: human ... HRH2(3274)

Descripción

Application

Ranitidine hydrochloride has been used as a reference compound for the development and validation of parallel artificial membrane permeability assay (PAMPA).

Biochem/physiol Actions

H₂ histamine receptor antagonist; anti-ulcer agent.

Ranitidine is mainly used to treat gastrointestinal impairment instigated by non-steroidal anti-inflammatory drugs (NSAIDs).

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS08,GHS07
• Palabra de advertencia: Danger
• Códigos de peligro: H315,H317,H319,H334,H335
• Indicaciones de precaución: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Órganos diana: Respiratory system
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 2
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• EPI (equipos de protección individual): Eyeshields, Gloves, type N95 (US)