Q2876

Quinacrine mustard dihydrochloride

≥85% (HPLC)

• Sinónimos: 2-Methoxy-6-chloro-9-(4-bis[β-chloroethyl]amino-1-methylbutylamino)acridine dihydrochloride, 9-[4-(Bis(2-chloroethyl)amino)-1-methylbutylamino]-6-chloro-2-methoxyacridine dihydrochloride
• Fórmula empírica (notación de Hill): C₂₃H₂₈Cl₃N₃O · 2HCl
• Número CAS: 4213-45-0
• Peso molecular: 541.77
• UNSPSC Code: 12352101
• NACRES: NA.32
• PubChem Substance ID: 24899329
• EC Number: 224-140-9
• Beilstein/REAXYS Number: 3819822
• MDL number: MFCD00043254

Propiedades

• Quality Segment: 200
• assay: ≥85% (HPLC)
• storage temp.: −20°C
• SMILES string: Cl[H].Cl[H].COc1ccc2nc3cc(Cl)ccc3c(NC(C)CCCN(CCCl)CCCl)c2c1
• InChI: 1S/C23H28Cl3N3O.2ClH/c1-16(4-3-11-29(12-9-24)13-10-25)27-23-19-7-5-17(26)14-22(19)28-21-8-6-18(30-2)15-20(21)23;;/h5-8,14-16H,3-4,9-13H2,1-2H3,(H,27,28);2*1H
• InChI key: JETDZFFCRPFPDH-UHFFFAOYSA-N

Descripción

General description

Quinacrine mustard dihydrochloride is a fluorescent acridine dye, also abbreviated as QM. In an aqueous solution, the chloroethyl groups rapidly lose chloride ions yielding aziridinium cations. These readily react with the carboxyl, thiol, and heterocyclic ring nitrogen groups of proteins and nucleic acids, or with other nucleophiles.

Application

Quinacrine mustard dihydrochloride is used to stain metaphase chromosomes. Recent applications include the Q-banding of maize and karyotyping of fish. The dye is also used as a vital stain for trypanosomes.

Información de seguridad

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H301 + H331,H317,H334,H361
• pcodes: P202 - P261 - P280 - P301 + P310 - P302 + P352 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges