P7443

L-α-fosfatidilcolina

from soybean, ≥99% (TLC), lyophilized powder

• Sinónimos: 1,2-Diacil-sn-glicero-3-fosfocolina, 3-sn-Fosfatidilcolina, L-α-lecitina, Azolectina, PC
• Número de CAS: 8002-43-5
• Beilstein/REAXYS Number: 5209585
• EC Number: 232-307-2
• UNSPSC Code: 12352211
• NACRES: NA.25

Propiedades

• biological source: soybean
• Quality Level: 200
• assay: ≥99% (TLC)
• form: lyophilized powder
• functional group: phospholipid
• lipid type: phosphoglycerides
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14-,21-20-/t40-/m1/s1
• InChI key: JLPULHDHAOZNQI-ZTIMHPMXSA-N

Descripción

General description

L-α-Phosphatidylcholine (PC) is an asymmetric molecule with glycerol backbone and occurs naturally in lecithin of egg yolk. It is a phospholipid and major choline source in mammalian cells. It is crucial for very low-density lipoprotein secretion in hepatocytes. It is essential for the acetylcholine synthesis functions to nourish the brain. PC plays a crucial role in lipid and lipoprotein metabolism. Deficiencies of enzymes in PC biosynthetic pathway leads to an array of metabolic disorder. Intracellular levels of hepatic PC to phosphatidylethanolamine (PE) ratio contributes to pathophysiology non-alcoholic fatty liver disease (NAFLD). It has anti-inflammatory functionality and is effective in treating inflammatory bowel disease. PC administration therapy is effective for treating benign symmetric lipomatosis.

Application

L-α-Phosphatidylcholine has been used:

• for liposome preparation
• as a component of stabilizer solution for preparing dispersed curcuminoid submicron particle (CSP)
• as a component of serum free substitute for whole blood cells

Biochem/physiol Actions

Un fosfolípido estructural principal del cerebro, que constituye aproximadamente el 15% de los lípidos totales; localizado principalmente en la materia gris.

Packaging

Packaged under Argon

Preparation Note

Prepared by a modification of the procedure of Singleton, W.S., et al., J. Am. Oil Chem. Soc., 42, 53 (1965).

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)