P5864

Proteoglycan from bovine nasal septum

chromatographically purified

• Sinónimos: Bovine Proteoglycan, Nasal Proteoglycan
• Número MDL: MFCD00212609
• Código UNSPSC: 12352202
• NACRES: NA.61

Propiedades

• origen biológico: bovine nasal septum
• Nivel de calidad: 100
• Formulario: powder
• técnicas: cell culture | stem cell: suitable
• Nº de acceso UniProt: F1MDS0
• temp. de almacenamiento: −20°C
• Información sobre el gen: bovine ... PRG4(280867)

Descripción

Descripción general

Proteoglycans are made up of a core protein to which glycosaminoglycan chains are linked covalently. They are present in many organs, and tissues and found abundantly in the vertebrate cartilage matrix. Proteoglycans are located in the extracellular and pericellular matrix of many cells.

Aplicación

Proteoglycan from bovine nasal septum contains 86% chondroitin sulfate and so has been used to study the effects of chondroitin sulfate proteoglycan in vitro. It has been shown to promote survival of neural stem cells in culture.

Proteoglycan from bovine nasal septum has been used in the induction of arthritis in mice.

Acciones bioquímicas o fisiológicas

Proteoglycans are involved in tissue organization and promote cell growth and specialized tissue maturation. They act as biological filters and regulate collagen fibrillogenesis, skin tensile strength, and neurite growth. Proteoglycans are also involved in modulating growth-factor activities, affecting tumor cell growth and invasion, and promoting corneal transparency.

Nota de preparación

Chromatographically purified using 7M urea on DEAE-cellulose by modified procedure by Antonopoulos.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)