P5780

Putrescine dihydrochloride

powder, BioReagent, suitable for cell culture

• Sinónimos: 1,4-Butanediamine dihydrochloride, 1,4-Diaminobutane dihydrochloride, Tetramethylenediamine dihydrochloride
• Fórmula lineal: NH₂(CH₂)₄NH₂ · 2HCl
• Número CAS: 333-93-7
• Peso molecular: 161.07
• UNSPSC Code: 12352207
• NACRES: NA.75
• PubChem Substance ID: 24898707
• EC Number: 206-375-9
• Beilstein/REAXYS Number: 3906680
• MDL number: MFCD00012526
• Assay: ≥97% (TLC)
• Form: powder

Propiedades

• Quality Segment: 200
• biological source: microbial, synthetic
• product line: BioReagent
• assay: ≥97% (TLC)
• form: powder
• technique(s): cell culture | mammalian: suitable
• mp: 280 °C (dec.) (lit.)
• solubility: H₂O: 100 mg/mL
• SMILES string: Cl[H].Cl[H].NCCCCN
• InChI: 1S/C4H12N2.2ClH/c5-3-1-2-4-6;;/h1-6H2;2*1H
• InChI key: XXWCODXIQWIHQN-UHFFFAOYSA-N

Descripción

General description

Listen to an Audio Overview
Putrescine is an end product of fatty acid metabolism in dead tissues. It is a volatile diamine with pungent odour. It is synthesized by the decarboxylation of ornithine in the presence of enzyme, ornithine decarboxylase. Molecular docking studies reveal the binding of putrescine to human receptors called the trace amine-associated receptors (TAAR6 and TAAR8), present in olfactory epithelium.

Application

Putrescine dihydrochloride has been used as medium component in F-12 + GlutaMax medium for mice ganglia culture, retinal ganglion cell culture and in HCT116 colon carcinoma cells for ornithine decarboxylase (ODC) assay.

Biochem/physiol Actions

Putrescine is regarded as a marker of stress in plants. External supplementation of putrescine helps wheat plants to overcome drought stress. It is crucial for cell proliferation in animals and modulates abscisic acid (ABA) levels during cold stress in Arabidopsis plants. It serves as an attractant for predators.

Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine.

Binds to the polyamine modulatory site of the NMDA receptor; potentiates NMDA-induced currents.

Información de seguridad

• Pictogramas: GHS06,GHS05
• Palabra de advertencia: Danger
• Códigos de peligro: H302,H311,H314,H330
• Indicaciones de precaución: P260 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B
• Clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 1
• EPI (equipos de protección individual): dust mask type N95 (US), Eyeshields, Gloves
• Punto de inflamación (°F): 113.0 °F - closed cup
• Punto de inflamación (°C): 45 °C - closed cup