P4532

(−)-N⁶-(2-Phenylisopropyl)adenosine

solid

• Sinónimos: (R)-N⁶-(1-Methyl-2-phenylethyl)adenosine, N⁶-(L-2-Phenylisopropyl)adenosine, R-(−)-PIA
• Fórmula empírica (notación de Hill): C₁₉H₂₃N₅O₄
• Número CAS: 38594-96-6
• Peso molecular: 385.42
• NACRES: NA.77
• PubChem Substance ID: 24277681
• UNSPSC Code: 12352200
• EC Number: 254-028-5
• MDL number: MFCD00069194
• Form: solid

Propiedades

• form: solid
• Quality Segment: 200
• potency: 1.17 nM K_i for A₁ receptors (using [³H]CHA in rat forebrain preparations)
• color: white
• solubility: H₂O: slightly soluble 0.3 mg/mL (Solutions may be stored for several days at 4°C.), 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.6 mg/mL (Solutions may be stored for several days at 4°C.)
• storage temp.: 2-8°C
• SMILES string: C[C@H](Cc1ccccc1)Nc2ncnc3n(cnc23)[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O
• InChI: 1S/C19H23N5O4/c1-11(7-12-5-3-2-4-6-12)23-17-14-18(21-9-20-17)24(10-22-14)19-16(27)15(26)13(8-25)28-19/h2-6,9-11,13,15-16,19,25-27H,7-8H2,1H3,(H,20,21,23)/t11-,13-,15-,16-,19-/m1/s1
• InChI key: RIRGCFBBHQEQQH-SSFGXONLSA-N
• Gene Information: human ... ADORA1(134)

Descripción

Biochem/physiol Actions

A₁ adenosine receptor agonist. Affinity for adenosine receptor is approx. 100× that of the (+)-isomer.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)