P4498

Pravastatin sodium salt hydrate

synthetic (organic), ≥98% (HPLC), HMG-CoA reductase inhibitor, powder

• Sinónimos: (βR, δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β, δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic acid sodium hydrate, Eptastatin sodium salt hydrate
• Fórmula empírica (notación de Hill): C₂₃H₃₅O₇Na · xH₂O
• Número CAS: 81131-70-6
• Peso molecular: 446.51 (anhydrous basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 329820206
• NACRES: NA.77
• MDL number: MFCD00887601
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Nombre del producto: Pravastatin sodium salt hydrate, ≥98% (HPLC), powder
• biological source: synthetic (organic)
• assay: ≥98% (HPLC)
• form: powder
• color: white
• mp: 171.2-173 °C
• solubility: H₂O: >10 mg/mL
• originator: Bristol-Myers Squibb
• storage temp.: 2-8°C
• SMILES string: [Na+].[H][C@@](O)(CC[C@H]1[C@@H](C)C=CC2=C[C@@H](O)C[C@H](OC(=O)[C@@H](C)CC)[C@]12[H])C[C@@H](O)CC([O-])=O
• InChI: 1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28);/q;+1/p-1/t13-,14-,16+,17+,18+,19-,20-,22-;/m0./s1
• InChI key: VWBQYTRBTXKKOG-IYNICTALSA-M
• Gene Information: human ... HMGCR(3156)

Descripción

General description

Pravastatin sodium is an orally effective hypocholesterolaemic agent which is structurally similar to lovastatin and compactin.

Application

Pravastatin sodium salt hydrate has been used in the enzymatic method to measure mevalonic acid in serum.

Biochem/physiol Actions

Competitive, water-soluble 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Inhibits cholesterol synthesis in vivo (Ki ~1 nM).

Pravastatin sodium is a competitive, water-soluble 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.

Features and Benefits

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)