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P4154

Sigma-Aldrich

Polyinosinic acid potassium salt

Homopolymer

Sinónimos:

Poly(I) potassium salt

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About This Item

Número de CAS:
26936-41-4
MDL number:
MFCD00131982
UNSPSC Code:
41106305
NACRES:
NA.51

biological source

synthetic (organic)

Quality Level

200

assay

≥98% (TLC)

form

lyophilized powder

solubility

water: 4.80-5.20 mg/mL, clear to hazy, colorless to faintly yellow

storage temp.

−20°C

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Application

Polyinosinic acid (Poly(I)) is a homopolymer of inosine that may be used with polycytidylic acid (poly(C)) to form the double-stranded homopolymer (Poly(I) • Poly(C)). TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. (Poly(I) • Poly(C)) is a used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.

Preparation Note

Prepared from IDP using polynucleotide phosphorylase.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Xingbo Wang et al.
Veterinary microbiology, 251, 108895-108895 (2020-10-31)
RNA binding ability and cellular distribution are important for nonstructural protein 1 (NS1) of influenza A virus to act as a viral regulatory factor to control virus life cycle. In this study, we identified that the N-terminal residues 19-21 of
Gennady Dvoryanchikov et al.
Nature communications, 8(1), 760-760 (2017-10-04)
Taste buds are innervated by neurons whose cell bodies reside in cranial sensory ganglia. Studies on the functional properties and connectivity of these neurons are hindered by the lack of markers to define their molecular identities and classes. The mouse
Overlapping and distinct roles of GRK5 in TLR2-, and TLR3-induced inflammatory response in vivo.
Packiriswamy N, Parvataneni S, Parameswaran N.
Cellular Immunology, 107-111 (2011)
Caiqi Ma et al.
International journal of oncology, 54(2), 572-584 (2018-11-30)
Gastric cancer is one of the most malignant tumor types, and its metastasis is a notable cause of mortality. Among the methods of tumor metastasis, lymphatic metastasis is the predominant one in gastric cancer. A previous study reported that the
CAF05: cationic liposomes that incorporate synthetic cord factor and poly(I:C) induce CTL immunity and reduce tumor burden in mice.
Hansen J, Lindenstr?m T, et al.
Cancer Immunology, Immunotherapy (2011)
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