P1639

Patulin

≥98.0% (HPLC)

• Sinónimos: Clavacin, Clavatin, Expansine, Gigantin, Leucopin, Mycoine C3, Terinin, 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one
• Fórmula empírica (notación de Hill): C₇H₆O₄
• Número CAS: 149-29-1
• Peso molecular: 154.12
• UNSPSC Code: 51102829
• NACRES: NA.85
• PubChem Substance ID: 24898227
• EC Number: 205-735-2
• Beilstein/REAXYS Number: 149675
• MDL number: MFCD00005858

Propiedades

• Quality Segment: 300
• assay: ≥98.0% (HPLC)
• form: powder
• solubility: water: 9-11 mg/mL
• antibiotic activity spectrum: fungi
• mode of action: cell membrane | interferes
• storage temp.: −20°C
• SMILES string: OC1OCC=C2OC(=O)C=C12
• InChI: 1S/C7H6O4/c8-6-3-4-5(11-6)1-2-10-7(4)9/h1,3,7,9H,2H2
• InChI key: ZRWPUFFVAOMMNM-UHFFFAOYSA-N

Descripción

General description

Patulin is a mycotoxin produced by a variety of molds, such as, Aspergillus and Penicillium. It is commonly found in apples. It is used as an inhibitor of potassium uptake and as an inducer of ion flux across cell membranes, potentially involving Na⁺-K⁺ dependent ATPase and to induce intra- and intermolecular protein crosslinking.

Application

Patulin has been used:

• to study patulin contamination of bottled wine
• in DNA-damaging activity of patulin in Escherichia coli
• in molecular cloning and functional characterization of two CYP619 cytochrome P450s involved in biosynthesis of patulin in Aspergillus clavatus

Biochem/physiol Actions

Mycotoxin with anti-bacterial, potassium uptake inhibitory, and possibly carcinogenic activities. It is used as an inhibitor of potassium uptake and as an inducer of ion flux across cell membranes, potentially involving Na⁺-K⁺ dependent ATPase and to induce intra- and intermolecular protein crosslinking.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Información de seguridad

• pictograms: GHS06
• signalword: Danger
• hcodes: H300,H315
• pcodes: P264 - P270 - P280 - P301 + P310 - P302 + P352 - P332 + P313
• Hazard Classifications: Acute Tox. 2 Oral - Skin Irrit. 2
• Clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• ppe: Eyeshields, Gloves