P1499

Pterostilbene

≥97% (HPLC), apoptosis inducer, solid

• Sinónimos: Pterocarpus marsupium, 3,5-Dimethoxy-4′-hydroxystilbene, 4-[(1E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenol
• Fórmula empírica (notación de Hill): C₁₆H₁₆O₃
• Número CAS: 537-42-8
• Peso molecular: 256.30
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724573
• NACRES: NA.77
• MDL number: MFCD00238710
• Assay: ≥97% (HPLC)
• Form: solid
• Storage condition: protect from light

Propiedades

• Nombre del producto: Pterostilbene, ≥97% (HPLC), solid
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: solid
• storage condition: protect from light
• solubility: DMSO: >20 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: COc1cc(OC)cc(\C=C\c2ccc(O)cc2)c1
• InChI: 1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+
• InChI key: VLEUZFDZJKSGMX-ONEGZZNKSA-N

Descripción

General description

Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene), an antioxidant is an analogue of resveratrol. It is present in blueberries, tree wood and some types of grapes.

Application

Pterostilbene has been used:

• to investigate its anti-oxidative stress activities and the involvement of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-antioxidant response element (ARE) signaling pathway
• to determine its effects on transcriptional activation of estrogen receptor-α (ERα) in hormone resistant breast cancer cells)
• to study its effects on the cytotoxicity of 2-chloroethyl ethyl sulphide (CEES) in human epidermoid carcinoma cells (A-431) through MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide)viability assay

Biochem/physiol Actions

Antioxidant, antiproliferative, apoptosis inducer, antihyperglycemic, antidiabetic.

Pterostilbene exhibits antineoplastic properties in some of the malignancies, hence it is considered as an active anticancer agent. It has the ability to stimulate apoptosis and block the viability of cell in estrogen-receptor positive and negative breast cancer cell lines.

Disclaimer

Air-sensitive

Información de seguridad

• pictograms: GHS05,GHS09
• signalword: Danger
• hcodes: H318,H411
• pcodes: P273 - P280 - P305 + P351 + P338 + P310
• Hazard Classifications: Aquatic Chronic 2 - Eye Dam. 1
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves