N3136

Naltrexone hydrochloride

≥99% (HPLC), powder, opioid receptor antagonist

• Sinónimos: Naltrexone HCl
• Fórmula empírica (notación de Hill): C₂₀H₂₃NO₄ · HCl
• Número CAS: 16676-29-2
• Peso molecular: 377.86
• NACRES: NA.77
• PubChem Substance ID: 24278051
• UNSPSC Code: 12352200
• EC Number: 240-723-0
• MDL number: MFCD00069324
• Beilstein/REAXYS Number: 3580333
• Form: powder

Propiedades

• Nombre del producto: Naltrexone hydrochloride,
• form: powder
• Quality Segment: 100
• originator: Novartis
• storage temp.: 2-8°C
• SMILES string: Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC6CC6
• InChI: 1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1
• InChI key: RHBRMCOKKKZVRY-ITLPAZOVSA-N
• Gene Information: human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)

Descripción

Application

Naltrexone hydrochloride has been used:

• as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model
• to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model
• in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H302
• Indicaciones de precaución: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• EPI (equipos de protección individual): dust mask type N95 (US), Eyeshields, Gloves