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Merck

M0695

Sigma-Aldrich

Anti-MOG (N-terminal) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-Myelin-oligodendrocyte Glycoprotein

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About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

buffered aqueous solution

reactividad de especies

human

técnicas

western blot: 1-2 μg/mL using recombinant human MOG protein

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... MOG(4340)

Descripción general

Myelin/oligodendrocyte glycoprotein (MOG) is an integral membrane glycoprotein belonging to the large immunoglobulin superfamily. It is a 26-28kDa glycoprotein localized on chromosome 6p21.3. It consists of an extracellular immunoglobulin-like domain and two hydrophobic regions. It is expressed on the surface of myelinating oligodendrocytes and external lamellae of myelin sheaths in the central nervous system.

Inmunógeno

synthetic peptide corresponding to amino acids 84-100 located near the N-terminal region of human MOGα1 isoform, conjugated to KLH. This sequence is identical in human MOGα1-3 and MOGβ1-4 isoforms, deleted in MOGα4 isoform, and identical in rat, mouse, and bovine MOG.

Aplicación

Anti-MOG (N-terminal) antibody produced in rabbit is suitable for western blot at a concentration of 1-2μg/mL using recombinant human MOG protein.

Acciones bioquímicas o fisiológicas

Myelin/oligodendrocyte glycoprotein (MOG) is a major component of the central nervous system. It is involved in several cellular processes including cellular adhesion, in the regulation of oligodendrocyte microtubule stability and facilitates the interactions between myelin and the immune system. It has been reported that MOG may be involved in the completion and/or maintenance of the myelin sheath, and in cell-cell communication. It has also been observed that mutation or polymorphisms in MOG gene could cause multiple sclerosis.

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Nanping Ai et al.
Neuropsychiatric disease and treatment, 15, 303-310 (2019-02-06)
To study the differences in immunopathogenesis based on chemokine profile in neuromyelitis optica patients positive for AQP4 antibodies or MOG antibodies. We measured 52 cytokines/chemokines using ELISA in 59 serum samples, which were divided into three groups according to CBA
Ying Peng et al.
Experimental and therapeutic medicine, 16(2), 950-958 (2018-08-17)
The present study aimed to detect myelin oligodendrocyte glycoprotein (MOG) and aquaporin-4 (AQP4) antibodies in serum specimens of patients with recurrent optic neuritis (RON) through establishing 293 cells with stable expression of MOG and the complete genomic sequence as the
Natalia Lubina-Dąbrowska et al.
Archivum immunologiae et therapiae experimentalis, 65(4), 325-338 (2017-03-17)
The aim of this study was to investigate the effects of interferon (IFN)-β1a and IFN-β1b treatment on inflammatory factors and myelin protein levels in the brain cortex of the Lewis rat experimental autoimmune encephalomyelitis (EAE), animal model of multiple sclerosis.
D Pham-Dinh et al.
Genomics, 29(2), 345-352 (1995-09-20)
Myelin/oligodendrocyte glycoprotein (MOG), a specific component of the central nervous system localized on the outermost lamellae of mature myelin, is a member of the immunoglobulin superfamily. We report here the organization of the human MOG gene, which spans approximately 17
T G Johns et al.
Journal of neurochemistry, 72(1), 1-9 (1999-01-14)
Myelin oligodendrocyte glycoprotein (MOG) is a quantitatively minor component of CNS myelin whose function remains relatively unknown. As MOG is an autoantigen capable of producing a demyelinating multiple sclerosis-like disease in mice and rats, much of the research directed toward

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