Saltar al contenido
Merck
Todas las fotos(6)

Key Documents

HPA040902

Sigma-Aldrich

Anti-MYO5B antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Sinónimos:

Anti-Kiaa1119, Anti-Myosin vb

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización


About This Item

UNSPSC Code:
12352203
Human Protein Atlas Number:
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

orthogonal RNAseq
independent
Learn more about Antibody Enhanced Validation

technique(s)

immunohistochemistry: 1:200- 1:500

immunogen sequence

NLMKKELEEERSRYQNLVKEYSQLEQRYDNLRDEMTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGLEKAAMDMTVFLK

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MYO5B(4645)

General description

Myosin VB (MYO5B) gene spanning 372,296 bases on genomic DNA with 42 exons is mapped to human chromosome 18q21.1. The gene codes for ubiquitously expressed myosin Vb protein. MYO5B contains N-terminal motor domain and C-terminal cargo-binding domain.

Immunogen

myosin VB recombinant protein epitope signature tag (PrEST)

Application

Anti-MYO5B antibody produced in rabbit has been used in immunostaining and western blot analysis.

Biochem/physiol Actions

Myosin VB (MYO5B) acts as a motor for actin dependent organelle trafficking. Mutation or loss of MYO5B gene is associated with the development of an autosomal recessive syndrome, microvillus inclusion disease (MVID). Decreased expression of the protein has been observed in patients of gastric cancer. Therefore, MYO5B might act as a potential biomarker for gastric cancer. MYO5B interacts with Ras-related proteins 8a and 11a (Rab8a–Rab11a) component and stimulates stretch-induced exocytosis in bladder umbrella cells.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST81706

Physical form

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

¿No encuentra el producto adecuado?  

Pruebe nuestro Herramienta de selección de productos.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

A Rab11a-Rab8a-Myo5B network promotes stretch-regulated exocytosis in bladder umbrella cells.
Khandelwal P
Molecular Biology of the Cell, 24(7), 1007-1019 (2013)
An overview and online
registry of microvillus
inclusion disease patients
and their MYO5B mutations
van der Velde KJ
Human Mutation, 34(12), 1597-1605 (2013)
Loss of MYO5B in mice recapitulates Microvillus Inclusion Disease and reveals an apical trafficking pathway distinct to neonatal duodenum.
Weis VG
Cellular and molecular gastroenterology and hepatology, 2(2), 131-157 (2016)
Victoria G Weis et al.
Cellular and molecular gastroenterology and hepatology, 2(2), 131-157 (2016-03-29)
Inactivating mutations in MYO5B cause severe neonatal diarrhea in Microvillus Inclusion Disease. Loss of active MYO5B causes the formation of pathognomonic inclusions and aberrations in brush border enzymes. We developed three mouse models of germline, constitutively intestinal targeted and inducible
Inactivation of MYO5B promotes invasion and motility in gastric cancer cells.
Dong W
Digestive Diseases and Sciences, 57(5), 1247-1252 (2012)

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico