H9250
Histone from calf thymus
Type II-A, lyophilized powder
Sinónimos:
histone type VIII-S
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About This Item
Número de CAS:
Beilstein/REAXYS Number:
1895465
MDL number:
UNSPSC Code:
41106305
NACRES:
NA.51
Productos recomendados
biological source
bovine (calf) thymus
Quality Level
type
Type II-A
form
lyophilized powder
application(s)
cell analysis
storage temp.
2-8°C
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General description
Histones are octameric proteins containing H3, H4, H2A and H2B. It is the core protein around which DNA is wound forming the nucleosome structure. The core histone proteins contain globular domains. Each protein is composed of basic amino acids at its N-terminal. The H2A has an extra amino acid at its C-terminal end forming a histone tail. The nucleosome structure is stabilized by the linker histones during chromatin condensation.
Application
Histone from calf thymus has been used:
- in methyltransferase reaction mixture for methyltransferase assay
- in in vitro binding assay, to explore the potential binding of the MORF4 (mortality factor on chromosome 4) - related gene on chromosome 15 (MRG15) chromo domain with histone
- in in vitro coculture assays, to stimulate liver resident Kupffer cells
Biochem/physiol Actions
The core histones are involved in histone-histone interactions and maintains the organization of the nucleosomal DNA. The histone tail helps in forming higher-order nucleosomal structures. The overall structure and action of chromatin fiber is regulated by histone modifications.
Features and Benefits
Do not confuse Sigma "Type" designations with the "Fraction" designations used by Luck and co-workers.
Preparation Note
Unfractionated whole histone
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
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Los clientes también vieron
Histones and histone modifications
Peterson CL, et al.
Current Biology, 14(14), R546-R551 (2004)
Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury
Huang H, et al.
Journal of Immunology, 191(5), 2665-2679 (2013)
Juan-Carlos Cabrera et al.
Glycobiology, 20(6), 775-786 (2010-03-05)
Plant cell walls undergo remodeling during growth and development and are the first target of many invading pathogens. Acidic pectin (homogalacturonans) binds calcium and forms chain dimers called egg boxes and even multimers at higher calcium ion concentrations. Chitosan, the
Wan-Shan Yang et al.
PLoS pathogens, 13(2), e1006216-e1006216 (2017-02-18)
Small ubiquitin-like modifier (SUMO) modification of chromatin has profound effects on transcription regulation. By using Kaposi's sarcoma associated herpesvirus (KSHV) as a model, we recently demonstrated that epigenetic modification of viral chromatin by SUMO-2/3 is involved in regulating gene expression
Adam F Kebede et al.
Nature structural & molecular biology, 24(12), 1048-1056 (2017-10-24)
Histones are highly covalently modified, but the functions of many of these modifications remain unknown. In particular, it is unclear how histone marks are coupled to cellular metabolism and how this coupling affects chromatin architecture. We identified histone H3 Lys14
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