F5386

Fibrin from human plasma

insoluble powder

• Número de CAS: 9001-31-4
• Número CE: 232-597-0
• Número MDL: MFCD00131058
• Código UNSPSC: 12352202
• NACRES: NA.61

Propiedades

• origen biológico: human plasma
• Nivel de calidad: 200
• Formulario: powder
• técnicas: indirect ELISA: suitable
• Nº de acceso UniProt: P02671; P02675; P02679
• cadena SMILES: N(CC(=O)NC)C(=O)CN
• InChI: 1S/C5H11N3O2/c1-7-5(10)3-8-4(9)2-6/h2-3,6H2,1H3,(H,7,10)(H,8,9)
• Clave InChI: BWGVNKXGVNDBDI-UHFFFAOYSA-N
• Información sobre el gen: human ... FGA(2243) , FGB(2244) , FGG(2266)

Descripción

Descripción general

Fibrin is produced from cross-linking of fibrinogen by thrombin. Fibrinogen is made up of two monomers each containing three polypeptide chains. Fibrinogen is a major plasma protein.

Aplicación

Fibrin from human plasma has been used:

• for in vitro cleavage of fibrinogen and fibrin
• as a reference for true component analysis (TCA) and principal component analysis (PCA) of Raman spectra
• as a reference in Raman spectroscopy to study the binding mechanisms and the binding efficiency of the different polyoxometalates (POMs)

Acciones bioquímicas o fisiológicas

Fibrin acts as an important bio-polymer in the primary blood clotting process. It creates a scaffold for infiltrating cells during tissue repair. Fibrin is widely used as a tissue sealant for tissue regeneration applications as it enables the formation of a biocompatible physical structure. It is also used in delivery systems for cells and bioactive molecules. The fibrin matrix resembles the native pancreas and can serve as a scaffold material for islet transplantation. Fibrin has been used in studies to obtain fibrin-specific monoclonal antibodies (mAbs). These mAbs may be used to determine their role in fibrin polymerization and use in fibrin quantification in blood plasma.

Nota de preparación

Prepared by clotting fibrinogen to yield a crosslinked fibrin

Cláusula de descargo de responsabilidad

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable