This product is intended for research use only and not suitable for human or veterinary use. Currently, a food grade product is not available.
E7881
Emodin
from Frangula bark, ≥90% (HPLC), casein Kinase 2 (CK2) inhibitor
Sinónimos:
1,3,8-Trihydroxy-6-methyl-9,10-anthracenedione, 1,3,8-Trihydroxy-6-methylanthraquinone, 6-Methyl-1,3,8-trihydroxyanthraquinone, Archin, Emodol, Frangula-emodin, Frangulic acid, Rheum emodin
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C15H10O5
Número CAS:
Peso molecular:
270.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
208-258-8
MDL number:
Beilstein/REAXYS Number:
1888141
Assay:
≥90% (HPLC)
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Servicio técnico
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Permítanos ayudarleNombre del producto
Emodin, from Frangula bark, ≥90% (HPLC)
biological source
Frangula bark
Quality Segment
assay
≥90% (HPLC)
solubility
DMSO: soluble, aqueous base: soluble, ethanol: soluble
storage temp.
2-8°C
SMILES string
Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1
InChI
1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
InChI key
RHMXXJGYXNZAPX-UHFFFAOYSA-N
Gene Information
human ... CSNK2A1(1457), CSNK2B(1460), ELA2(1991), NFKB1(4790), NKAP(79576), NKRF(55922)
General description
Emodin is an anthraquinone derivative, extracted from rhubarb (Rheum palmatum). It has antibacterial, anti-neoplastic, anti-inflammatory and anti-angiogenesis properties. Emodin exhibits cytotoxic effects, apoptosis and stimulates the expression of hypoxia-inducible factor 1α, glutathione S-transferase P and N-acetyltransferase. It prevents the growth of prostate cancer cells. Emodin is used to treat constipation and hemorrhoid. It displays immunosuppressive and anti-diabetic effects.
Application
Emodin has been used:
- to investigate its regulatory mechanisms on lipopolysaccharide (LPS)-induced inflammatory injury in myocarditis
- as a reference standard for the development and validation of high performance liquid chromatography (HPLC)-photodiode array (PDA) assay method
- to inhibit Tau aggregation
- for direct binding assay
Biochem/physiol Actions
Inhibitor of NF-κB activation and adhesion molecule expression. Casein Kinase 2 (CK2) inhibitor.
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Este artículo | |||
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| description from Frangula bark, ≥90% (HPLC) | description phyproof® Reference Substance | description United States Pharmacopeia (USP) Reference Standard | description A cell-permeable, reversible, substrate competitive and potent p56lck tyrosine kinase inhibitor (IC50 = 18.5 µM). |
| assay ≥90% (HPLC) | assay ≥90.0% (HPLC) | assay - | assay ≥90% (HPLC) |
| Quality Level 200 | Quality Level - | Quality Level - | Quality Level 100 |
| storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility aqueous base: soluble, DMSO: soluble, ethanol: soluble | solubility - | solubility - | solubility ethanol: soluble, DMSO: 1 mg/mL, aqueous base: soluble |
| Gene Information human ... CSNK2A1(1457), CSNK2B(1460), ELA2(1991), NFKB1(4790), NKAP(79576), NKRF(55922) | Gene Information - | Gene Information - | Gene Information - |
| biological source Frangula bark | biological source - | biological source - | biological source - |
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Warning
Códigos de peligro
Indicaciones de precaución
Hazard Classifications
Acute Tox. 4 Oral
Clase de almacenamiento
11 - Combustible Solids
Punto de inflamación (°F)
Not applicable
Punto de inflamación (°C)
Not applicable
EPI (equipos de protección individual)
dust mask type N95 (US), Eyeshields, Gloves
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