E5641
11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid
~100 μg/mL in ethanol, ≥95%
Sinónimos:
(±)11,12-EpETrE, 11,12-EET
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About This Item
Fórmula empírica (notación de Hill):
C20H32O3
Número de CAS:
Peso molecular:
320.47
Número CE:
Número MDL:
Código UNSPSC:
12352211
ID de la sustancia en PubChem:
NACRES:
NA.25
Productos recomendados
Nivel de calidad
Ensayo
≥95%
concentración
~100 μg/mL in ethanol
tipo de lípido
omega FAs
temp. de almacenamiento
−20°C
cadena SMILES
CCCCC\C=C\CC1OC1C\C=C\C\C=C\CCCC(O)=O
InChI
1S/C20H32O3/c1-2-3-4-5-9-12-15-18-19(23-18)16-13-10-7-6-8-11-14-17-20(21)22/h6,8-10,12-13,18-19H,2-5,7,11,14-17H2,1H3,(H,21,22)/b8-6+,12-9+,13-10+
Clave InChI
DXOYQVHGIODESM-ATELOPIESA-N
Envase
Packaged under argon
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Eye Irrit. 2 - Flam. Liq. 2
Código de clase de almacenamiento
3 - Flammable liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
48.2 °F - closed cup
Punto de inflamabilidad (°C)
9 °C - closed cup
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Yindi Ding et al.
The Journal of pharmacology and experimental therapeutics, 350(1), 14-21 (2014-04-26)
Cytochrome P450-derived epoxides of arachidonic acid [i.e., the epoxyeicosatrienoic acids (EETs)] are important lipid signaling molecules involved in the regulation of vascular tone and angiogenesis. Because many actions of 11,12-cis-epoxyeicosatrienoic acid (EET) are dependent on the activation of protein kinase
L Yang et al.
British journal of clinical pharmacology, 80(1), 28-44 (2015-02-07)
There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ischaemic damage, resulting in attenuation of animal models of cardiovascular risk
Yong Zhou et al.
Shock (Augusta, Ga.), 47(5), 638-645 (2016-10-19)
Acute lung injury (ALI) is characterized by rapid alveolar injury, vascular leakage, lung inflammation, neutrophil accumulation, and induced cytokines production leading to lung edema. The mortality rate of patients suffering from ALI remains high. Epoxyeicosatrienoic acids (EETs) are cytochrome P450-dependent
Xiaojing Wang et al.
Scandinavian journal of immunology, 90(3), e12791-e12791 (2019-05-28)
The epoxyeicosatrienoic acids (EETs) are products of cytochrome P450 epoxygenases and have recently been found to have an anti-inflammatory activity. However, the role of EETs in non-alcoholic steatohepatitis has not been fully understood. In this study, we investigated the protective
Annemarieke E Loot et al.
PloS one, 7(9), e46065-e46065 (2012-10-03)
In the systemic circulation, 11,12-epoxyeicosatrienoic acid (11,12-EET) elicits nitric oxide (NO)- and prostacyclin-independent vascular relaxation, partially through the activation of large conductance Ca(2+)-activated potassium (BK) channels. However, in the lung 11,12-EET contributes to hypoxia-induced pulmonary vasoconstriction. Since pulmonary artery smooth
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