E4389

β-Estradiol-Water Soluble

BioReagent, suitable for cell culture

• Sinónimos: Cyclodextrin-encapsulated 17β-estradiol
• Número MDL: MFCD00133134
• Código UNSPSC: 12352209
• ID de la sustancia en PubChem: 329799056
• NACRES: NA.77
• origen biológico: synthetic (organic)
• Formulario: powder

Propiedades

• origen biológico: synthetic (organic)
• Nivel de calidad: 200
• esterilidad: non-sterile
• Línea del producto: BioReagent
• Formulario: powder
• técnicas: cell culture | mammalian: suitable
• solubilidad: H₂O: 25 mg/mL, clear to slightly hazy
• Condiciones de envío: ambient
• temp. de almacenamiento: room temp
• cadena SMILES: C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CC[C@@H]2O.C[C@@H]5[C@@H](O)[C@@H]6O[C@H](CO)[C@H]5O[C@H]7O[C@H](CO)[C@@H](O[C@H]8O[C@H](CO)[C@@H](O[C@H]9O[C@H](CO)[C@@H](O[C@H]%10O[C@H](CO)[C@@H](O[C@H]%11O[C@H](CO)[C@@H](O[C@H]%12O[C@H](CO)[C@@H](O6)[C@H](O)[C@H]%12O)[C@H](O)[C@H]%11O)[C@H](O)[C@H]%10O)[C@H](O)[C@H]9O)[C@H](O)[C@H]8OCCCO)[C@H](O)[C@H]7O
• InChI: 1S/C46H78O35.C18H24O2/c1-12-20(55)40-68-13(5-48)32(12)75-41-26(61)25(60)37(18(10-53)69-41)81-46-39(67-4-2-3-47)31(66)38(19(11-54)74-46)80-45-30(65)24(59)36(17(9-52)73-45)79-44-29(64)23(58)35(16(8-51)72-44)78-43-28(63)22(57)34(15(7-50)71-43)77-42-27(62)21(56)33(76-40)14(6-49)70-42;1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h12-66H,2-11H2,1H3;3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31+,32+,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-;14-,15-,16+,17+,18+/m11/s1
• Clave InChI: XMURHKLFGRLVRW-JKDYGSMVSA-N

Descripción

Descripción general

β-estradiol is a natural human estrogen. It is vital for the growth of breast and reproductive epithelia, maturation of long bones and development of secondary sexual characteristics. Estradiol is produced by immature germ cells, spermatozoa, Leydig cells and Sertoli cells. β-estradiol acts as a menopausal hormones. It is involved in replacement therapy for female hypogonadism or primary ovarian failure. Reduced levels of β-estradiol are linked to heart disease and osteoporosis. Estradiol plays a critical role in proliferation, modulation of ion transport and control of apoptosis in Sertoli cells. It maintains sperm concentration, motility and morphology.

Aplicación

β-estradiol has been used:

• to culture differentiated adipocytes
• for estradiol treatment in rats
• for oocyte maturation in vitro

β-Estradiol is used to study cell differentiation and transformations (tumorigenicity). This product is not recommended for use in binding assays.

Envase

Package size based on estradiol

Otras notas

Contains 40-55 mg estradiol per gram of solid; balance 2-hydroxypropyl-β-cyclodextrin.

Información de seguridad

• Pictogramas: GHS08,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H351,H360FD,H362,H410
• Consejos de prudencia: P202 - P260 - P263 - P264 - P273 - P308 + P313
• Clasificaciones de peligro: Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3