E1253

Estriol

synthetic (organic), ≥97%, immunomodulatory , powder

• Sinónimos: 1,3,5(10)-Estratriene-3,16α,17β-triol, 16α-Hydroxyestradiol, 3,16α,17β-Trihydroxy-1,3,5(10)-estratriene
• Fórmula empírica (notación de Hill): C₁₈H₂₄O₃
• Número CAS: 50-27-1
• Peso molecular: 288.38
• NACRES: NA.77
• PubChem Substance ID: 24894396
• UNSPSC Code: 51111800
• EC Number: 200-022-2
• MDL number: MFCD00003691
• Beilstein/REAXYS Number: 2508172
• Assay: ≥97%
• Form: powder

Propiedades

• Nombre del producto: Estriol, ≥97%
• biological source: synthetic (organic)
• Quality Segment: 200
• sterility: non-sterile
• assay: ≥97%
• form: powder
• mp: 280-282 °C (lit.)
• solubility: pyridine: 50 mg/mL, clear, colorless to faintly brownish-yellow
• shipped in: ambient
• storage temp.: room temp
• SMILES string: C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1C[C@@H](O)[C@@H]2O
• InChI: 1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1
• InChI key: PROQIPRRNZUXQM-ZXXIGWHRSA-N
• Gene Information: human ... SERPINA6(866) ; mouse ... Esr1(13982) ; rat ... Ar(24208)

Descripción

Application

Estriol has been used as a sex hormone to determine its binding constants to insulin (INS), the insulin receptor (IR), and INS-like peptides derived from the IR.

Biochem/physiol Actions

Estriol is a metabolite of 17β-estradiol with much lower biological activity. It is the primary estrogen found in the urine. Large quantities of estriol and estrone are produced by the placenta during pregnancy. These are also the primary estrogens produced by adipose tissue in men and post-menopausal women. Estriol may exhibit immunomodulatory benefits against various diseases such as autoimmune, inflammatory, and neurodegenerative conditions.

Información de seguridad

• pictograms: GHS08
• signalword: Danger
• hcodes: H351,H360FD,H362
• pcodes: P201 - P202 - P260 - P263 - P264 - P308 + P313
• Hazard Classifications: Carc. 2 - Lact. - Repr. 1A
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges