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Merck

E0881

Sigma-Aldrich

Elastatinal

powder

Sinónimos:

(2S)-2-[(4S)-2-Amino-1,4,5,6-tetrahydro4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl-L-glutamamide

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About This Item

Fórmula empírica (notación de Hill):
C21H36N8O7
Número de CAS:
Peso molecular:
512.56
Beilstein/REAXYS Number:
873543
EC Number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77

product name

Elastatinal, microbial

biological source

microbial

Quality Level

form

powder

solubility

water: 20 mg/mL, clear, faintly yellow to yellow

storage temp.

−20°C

SMILES string

[H]C(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)N[C@@H](CC(C)C)C(O)=O)[C@]1([H])CCNC(=N)N1

InChI

1S/C21H36N8O7/c1-10(2)8-14(19(34)35)28-21(36)29-16(12-6-7-24-20(23)27-12)18(33)26-13(4-5-15(22)31)17(32)25-11(3)9-30/h9-14,16H,4-8H2,1-3H3,(H2,22,31)(H,25,32)(H,26,33)(H,34,35)(H3,23,24,27)(H2,28,29,36)/t11-,12-,13-,14-,16-/m0/s1

InChI key

IJWCGVPEDDQUDE-YGJAXBLXSA-N

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Biochem/physiol Actions

Potent, irreversible elastase inhibitor. Elastatinal is a much stronger inhibitor of elastase from pancreas than from leucocytes.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificados de análisis (COA)

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Los clientes también vieron

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M K Marschütz et al.
Biomaterials, 21(14), 1499-1507 (2000-06-29)
A drug-carrier matrix has been developed which protects embedded insulin from degradation by the luminally secreted serine-proteases trypsin (EC 3.4.21.4), chymotrypsin (EC 3.4.21.1) and elastase (EC 3.4.21.36) in vitro. Increasing amounts of the Bowman-Birk inhibitor (BBI) and elastatinal, respectively, were
Valentina Grano et al.
Biotechnology progress, 20(3), 968-974 (2004-06-05)
The inhibitory power of three different active Nylon membranes, separately loaded with three different protease inhibitors, was studied with the aim of reducing the increased elastase concentration occurring during hemodialysis or extracorporeal blood circulation in patients undergoing cardiopulmonary bypass. Chemical
T Yagi et al.
Cancer letters, 10(4), 301-307 (1980-10-01)
Effects of elastatinal, a protease inhibitor, on DNA repair and its cytotoxicity were investigated in normal human, xeroderma pigmentosum and Chinese hamster V79 cells. There were no effects of elastatinal on DNA repair and UV-induced sister chromatid exchanges, and all
P Paul et al.
Carcinogenesis, 2(4), 255-259 (1981-01-01)
Microbial protease inhibitors elastatinal and leupeptin were tested for cytotoxicity and for effects on spontaneous and u.v.-induced 6-thioguanine-resistant (6TGr) mutation and sister-chromatid exchange (SCE) in V79 Chinese hamster cells. Continuous treatment with elastatinal exhibited marked cytotoxicity, while leupeptin was almost
M M Hardy et al.
The Journal of biological chemistry, 269(28), 18535-18540 (1994-07-15)
In this study, we evaluated the ability of low molecular weight manganese-based superoxide dismutase mimetics to attenuate neutrophil-mediated oxygen radical damage to human aortic endothelial cells in vitro. Human neutrophils, when exposed to tumor necrosis factor-alpha and the complement compound

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