If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf
D1515
Doxorrubicina hydrochloride
98.0-102.0% (HPLC)
Sinónimos:
Adriamicina, DOX, Hidroxidaunorrubicina hydrochloride
About This Item
Productos recomendados
origen biológico
synthetic (organic)
Ensayo
98.0-102.0% (HPLC)
Formulario
powder
mp
216 °C (dec.) (lit.)
solubilidad
water: 50.0-52.0 mg/mL, clear, orange to red
espectro de actividad antibiótica
viruses
Modo de acción
DNA synthesis | interferes
temp. de almacenamiento
2-8°C
cadena SMILES
Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
InChI
1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
Clave InChI
MWWSFMDVAYGXBV-RUELKSSGSA-N
Información sobre el gen
human ... TOP2A(7153)
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Categorías relacionadas
Descripción general
La doxorrubicina también induce la generación de especies reactivas del oxígeno (ROS), que dañan aún más el ADN, las proteínas y las membranas. Ejerce actividad citotóxica, antitumoral, anticancerígena y antineoplásica y encuentra aplicación en la investigación sobre el cáncer, la metabolómica, la biología celular y la bioquímica.[4]
Aplicación
- en ensayos de viabilidad celular[5]
- en el ensayo del MTT (bromuro de 3-(4,5-dimetiltiazol-2-il)-2,5-difeniltetrazolio)[6]
- como medicamento en la administración de fármacos en micropartículas compuestas de PLGA[7]
- para desarrollar células HepG2 resistentes a la doxorrubicina (HepG2-DR) y células K562 (K562-DR)[8]
Acciones bioquímicas o fisiológicas
Características y beneficios
- Antibiótico de gran calidad adecuado para múltiples aplicaciones experimentales
- Ideal para investigación en biología celular, metabolómica y bioquímica.
Nota de preparación
Almacenamiento y estabilidad
Otras notas
Producto relacionado
producto comparable
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
Código de clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Elija entre una de las versiones más recientes:
Certificados de análisis (COA)
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Artículos
Explore how antibiotics, particularly quinolones, inhibit nucleic acid synthesis by targeting topoisomerases, crucial for DNA replication processes.
Explore how antibiotics, particularly quinolones, inhibit nucleic acid synthesis by targeting topoisomerases, crucial for DNA replication processes.
Explore how antibiotics, particularly quinolones, inhibit nucleic acid synthesis by targeting topoisomerases, crucial for DNA replication processes.
Explore how antibiotics, particularly quinolones, inhibit nucleic acid synthesis by targeting topoisomerases, crucial for DNA replication processes.
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How can I determine the shelf life / expiration / retest date of this product?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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How to store after reconstitution and for how long is it stable?
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Aliquots are stable for up to 3 months at -20°C or for up to 6 months at -70°C. Avoid repeated freeze/thaw cycles.
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What is the difference between Doxorubicin hydrochloride Products D1515 and 44583?
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The D1515 and 44583 Doxorubicin HCl products are physically identical. Each has a minimum purity specification of 98%. However, the 44583 product option is tested for suitability in fluorescence applications while the D1515 is assigned basic tests for general research use.
The following links taken from the peer reviewed papers may be of interest:
https://www.sigmaaldrich.com/search/d1515?focus=papers&page=1&perpage=30&sort=relevance&term=d1515&type=citation_searchHelpful?
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Si può prolungare la stabilità del prodotto D1515 sciolto in soluzione acquosa e successivamente conservato a -20°C?
1 answer-
Solution stability studies have not been performed on this product, however, the available literature suggests that solutions are most stable refrigerated. It is recommended to add 3 - 5% glucose or lactose as a stabilizer for long-term storage. Commercially available solutions were found to be stable for at least 1 month at -20°C and up to 1 year at 4°C.
This product, in solution, will degrade in alkaline pH conditions or when exposed to light for extended periods.
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Whta is the pka and logP of Doxorubicin hydrochloride ID D1515
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See the link below to DrugBank Online for these data:
https://go.drugbank.com/salts/DBSALT000060Helpful?
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Is this product suitable for in vivo applications?
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This product has not been tested for in vitro or in vivo use. However, the listed Peer-Reviewed Papers suggest that customers have been successful in these applications. Note that the product is not tested for endotoxin and the solution would require filter sterilization prior to use.
Please view the peer-reviewed papers here: https://www.sigmaaldrich.com/search/d1515?focus=papers&page=1&perpage=30&sort=relevance&term=d1515&type=citation_search.
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How can I store a solution of Product D1515, Doxorubicin hydrochloride?
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Aqueous solutions are unchanged after one month at 5 °C but unstable at higher temperatures or at either acid or alkaline pH. Several studies cite that stability is related to pH, exposure to light and the medium used for storage. Doxorubicin hydrochloride is subject to light degradation at °C in the dark in 5% glucose, pH 4.7 (or 3.3% glucose + 0.3% sodium chloride, pH 4.4), solutions were stable (5% or less change) for at least 4 weeks.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What can be used to make a solution of Product D1515, Doxorubicin hydrochloride?
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The solubility of doxorubicin is tested in water (50 mg/mL), yielding a clear orange to red solution.
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