Here is the link to our Biochemical Solubility table:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/287/917/c3045inf.pdf
For the Cell Culture Tested grade of this product, C3045, three options are provided: Serum, Tween and Ethanol.
Note that if Serum is used as the solvent, it may already contain some Cholesterol. The "Tween" is referring to an aqueous solution of either TWEEN 20 or TWEEN 80. Also, Ethanol can be used to make a stock solution, before supplementing the culture medium; consider perhaps a 100X solution in ethanol, which would give a concentration of 1 percent ethanol in the medium.
C8667
Colesterol
Sigma Grade, ≥99%
Cholesterol
1 of 1 reviewers received a sample product or took part in a promotion
Sinónimos:
3β-Hidroxi-5-colesteno, 5-Colesten-3β-ol
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Fórmula empírica (notación de Hill):
C27H46O
Número CAS:
Peso molecular:
386.65
NACRES:
NA.77
PubChem Substance ID:
eCl@ss:
39023139
UNSPSC Code:
12352111
EC Number:
200-353-2
MDL number:
Beilstein/REAXYS Number:
1915888
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Servicio técnico
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Permítanos ayudarlebiological source
sheep wool
grade
Sigma Grade
assay
≥99%
form
powder
bp
360 °C (lit.)
mp
147-149 °C (lit.)
solubility
water: soluble 0.00003 g/L at 20 °C
density
1.067 g/mL at 25 °C (lit.)
application(s)
advanced drug delivery
shipped in
ambient
storage temp.
−20°C
SMILES string
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI
1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChI key
HVYWMOMLDIMFJA-DPAQBDIFSA-N
Gene Information
human ... POLA1(5422), TOP2A(7153)
rat ... Ar(24208), Polb(29240)
Application
Patrón para cromatografía
El colesterol se utilizó para preparar complejos inmunoestimulantes para intensificar las respuestas celular y humoral.[1] Se incorporó en el pienso animal para estudiar el efecto de las dietas ricas en colesterol.
Biochem/physiol Actions
Componente principal de todas las membranas biológicas; ~ el 25 % de todos los lípidos cerebrales es colesterol.
El colesterol es un lípido que constituye hasta el 20-25% de los componentes estructurales de las membranas celulares. Determina la fluidez y la permeabilidad de la membrana, haciéndola permeable al agua pero no a los iones ni a los protones. El colesterol también regula las funciones de las proteínas transportadoras y de comunicación presentes en las membranas plasmáticas.[2] Las principales lugares de síntesis del colesterol son el intestino delgado y el hígado.[3]
Preparation Note
El monohidratado de colesterol produce una disolución transparente, de incolora a amarillo pálido en alcohol caliente. También es soluble en acetona, dioxano, acetato de etilo, benceno, éter de petróleo (bencina), aceites y grasas, y en disoluciones acuosas de sales biliares. Las disoluciones deben estar protegidas de la luz.
1 of 1
Este artículo | |||
|---|---|---|---|
| biological source sheep wool | biological source sheep wool | biological source - | biological source sheep |
| assay ≥99% | assay ≥92.5% (GC) | assay - | assay - |
| grade Sigma Grade | grade - | grade certified reference material, pharmaceutical secondary standard | grade pharmaceutical primary standard |
| solubility water: soluble 0.00003 g/L at 20 °C | solubility water: soluble 0.00003 g/L at 20 °C | solubility water: soluble 0.00003 g/L at 20 °C | solubility - |
| form powder | form powder | form powder | form - |
| storage temp. −20°C | storage temp. room temp | storage temp. -10 to -25°C | storage temp. −20°C |
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Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| C8667-5G | 04061835543632 |
| C8667-100G | 04061835543601 |
| C8667-500MG | 04061835543625 |
| C8667-25G | 04061835521746 |
| C8667-1G | 04061835543618 |
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how to prepare for cell culture? thank you
1 answer-
Helpful?
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What is the best temperature for storage for 5 mg/mL solutions in ethanol? Can they be stored at 4C? Thank you!
1 answer-
The stability of this material in solution at 2-8°C has not been evaluated. Solutions prepared in Chloroform, in aliquots and protected from light, are stable for at least 1 year when stored at -20°C. Solutions prepared in Ethanol are expected to be similarly stable.
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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Buongiorno, volevo chiedere cortesemente quale sia l'origine del prodotto
1 answer-
This product is derived from sheep wool. The origin information of this product will be listed on the lot-specific Certificate of Origin. Please navigate to the ‘DOCUMENTATION’ section of the Product Detail Page to access a Certificate under the ‘Certificate of Origin’ tab:
https://www.sigmaaldrich.com/product/sigma/c8667#product-documentationHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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Hi, I want to know if this is from plant or sheep wool?
1 answer-
As mentioned in the PROPERTIES section of the product page, this material is from sheep wool.
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