C7897

Clonidine hydrochloride

solid

• Sinónimos: 2-(2,6-Dichloroanilino)-2-imidazoline hydrochloride
• Fórmula empírica (notación de Hill): C₉H₉Cl₂N₃ · HCl
• Número de CAS: 4205-91-8
• Peso molecular: 266.55
• Beilstein: 4163525
• Número CE: 224-121-5
• Número MDL: MFCD00036705
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24277750
• NACRES: NA.77

Propiedades

• Formulario: solid
• color: white
• solubilidad: H₂O: soluble; methanol: soluble
• emisor: Boehringer Ingelheim
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Cl[H].Clc1cccc(Cl)c1NC2=NCCN2
• InChI: 1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H
• Clave InChI: ZNIFSRGNXRYGHF-UHFFFAOYSA-N
• Información sobre el gen: human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

Descripción

Descripción general

Clonidine hydrochloride has antihypertensive[1] analgesic[2] and antidiarrheal properties.[3] It lowers short-circuit current, blocks anion secretion, improves mucosal absorption of fluids and electrolytes in vitro.[3] Clonidine is used to treat attention deficit and hyperactivity disorders (ADHD),[4] menopausal flushing, drug withdrawal and Tourette′s syndrome.[5]

Aplicación

Clonidine hydrochloride has been used as an adrenergic receptor (ADRA2A) agonist:

• in ex vivo leptin release assay [6]
• to study its effects on pain hypersensitivity in 6-OHDA lesioned rats[7]
• to study its influence on the sleep of larval zebrafish[8]
• to manipulate noradrenaline and examine its influence on behavioral flexibility and motivation[9]

Clonidine hydrochloride has been used:

• to reduce central noradrenaline levels[9]
• to inhibit allyl isothiocyanate (AITC) sensitized thermal aversion[10]
• to attenuate thermal and mechanical pain hypersensitivity in rats[11]
• as a positive control for pertussis toxin (PTX)[12]

Acciones bioquímicas o fisiológicas

α₂-adrenoceptor agonist; I₁ imidazoline binding site ligand.

Clonidine hydrochloride is used for management of hypertension in pregnant women.[13] In addition, it also acts as a therapeutic for neonatal abstinence syndrome.[14] Clonidine hydrochloride binds to central α-adrenergic receptors and reduces the efferent sympathetic neuronal vasoconstrictor tone to the heart, kidneys and peripheral vasculature leading to vasodilatation and reduction in the blood pressure.[15]

Características y beneficios

This compound is featured on the Imidazoline Binding Sites page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H301,H330
• Consejos de prudencia: P301 + P310 + P330 - P304 + P340 + P310
• Clasificaciones de peligro: Acute Tox. 1 Inhalation - Acute Tox. 3 Oral
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges