C6643

Clofibrate

liquid

• Sinónimos: 2-(4-Chlorophenoxy)-2-methylpropionic acid ethyl ester, Ethyl 2-(4-chlorophenoxy)-2-methylpropionate, Ethyl 2-(4-chlorophenoxy)isobutyrate
• Fórmula empírica (notación de Hill): C₁₂H₁₅ClO₃
• Número CAS: 637-07-0
• Peso molecular: 242.70
• MDL number: MFCD00000615
• UNSPSC Code: 12352200
• NACRES: NA.77
• PubChem Substance ID: 24278085
• EC Number: 211-277-4
• Beilstein/REAXYS Number: 1913459
• Form: liquid

Propiedades

• form: liquid
• Quality Segment: 200
• color: clear colorless
• density: 1.14 g/mL at 25 °C (lit.)
• originator: Wyeth
• storage temp.: 2-8°C
• SMILES string: CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1
• InChI: 1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
• InChI key: KNHUKKLJHYUCFP-UHFFFAOYSA-N
• Gene Information: human ... PPARA(5465) ; mouse ... Ppara(19013)

Descripción

Application

Clofibrate has been used:

• as a quinolinate phosphoribosyltransferase (QPRT) agonist to study its effects on hepatitis C virus (HCV) infection
• as peroxisome proliferated activated receptor (PPAR) agonist to study its effects on autophagy in rat liver cells
• as a hepatotoxicant to study its effects on gene expression in primary rat hepatocytes

Biochem/physiol Actions

Clofibrate is a peroxisome proliferated activated receptor α (PPARα) agonist. It is a fibric acid derivative and has a therapeutic effect on hypertriglyceridemia and hyperlipoproteinemia type III. Clofibrate participates in lowering the very-low-density lipoprotein (VLDL) and cholesterol levels in hyperlipoproteinemia type III patients. It facilitates the decrease of total serum bilirubin concentration in Gilbert′s syndrome.

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Información de seguridad

• Pictogramas: GHS05,GHS07
• Palabra de advertencia: Danger
• Códigos de peligro: H302,H315,H318,H335
• Indicaciones de precaución: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Órganos diana: Respiratory system
• Clase de almacenamiento: 10 - Combustible liquids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): 235.4 °F - closed cup
• Punto de inflamación (°C): 113 °C - closed cup
• EPI (equipos de protección individual): Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter