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C6492

Sigma-Aldrich

Ciproxifan hydrochloride

≥98% (HPLC), solid

Sinónimos:

Cyclopropyl[4-[3-(1H-imidazol-4-yl)propoxyl]phenyl]-methanone hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C16H18N2O2 · HCl
Número de CAS:
1049741-81-2
Peso molecular:
306.79
Número MDL:
MFCD08705321
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24724449
NACRES:
NA.77

Nivel de calidad

100

Ensayo

≥98% (HPLC)

Formulario

solid

condiciones de almacenamiento

desiccated
under inert gas

color

off-white

solubilidad

DMSO: 30 mg/mL
water, high purity: 30 mg/mL

temp. de almacenamiento

2-8°C

cadena SMILES

Cl.O=C(C1CC1)c2ccc(OCCCc3c[nH]cn3)cc2

InChI

1S/C16H18N2O2.ClH/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14;/h5-8,10-12H,1-4,9H2,(H,17,18);1H

Clave InChI

PWAPSKMHZQQTRJ-UHFFFAOYSA-N

Acciones bioquímicas o fisiológicas

Ciproxifan belongs to a novel chemical series of histamine H3-receptor antagonists. In vitro, it behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. Ciproxifan appears to be an orally bioavailable, extremely potent and selective H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.
H3 histamine receptor antagonist.

Características y beneficios

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000208199
0000208198
039K4608V
039K46081
039K4608

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Yan Chen et al.
Frontiers in pharmacology, 12, 599393-599393 (2021-06-18)
NLRP3 inflammasome has been implicated in impaired post-injury muscle healing and in muscle atrophy. Histamine receptors play an important role in inflammation, but the role of histamine H3 receptor (H3R) in myocyte regeneration and in the regulation of NLRP3 inflammasome
Tao Luo et al.
CNS neuroscience & therapeutics, 23(4), 301-309 (2017-02-09)
Exposure to pharmacological concentration of inhaled anesthetics such as isoflurane can cause short- or long-term cognitive impairments in preclinical studies. The selective antagonists of the histamine H3 receptors are considered as a promising group of novel therapeutic agents for the
Nayeli Rivera-Ramírez et al.
Neurochemistry international, 101, 38-47 (2016-11-05)
The histamine H3 receptor (H3R) is abundantly expressed in the Central Nervous System where it regulates several functions pre and postsynaptically. H3Rs couple to Gαi/o proteins and trigger or modulate several intracellular signaling pathways, including the cAMP/PKA pathway and the
Cecilia Flores-Clemente et al.
Neuroscience letters, 641, 77-80 (2017-01-28)
There is evidence for genetic polymorphism within the human histamine H
Emil Trofimiuk et al.
Behavioural brain research, 283, 145-153 (2015-02-03)
Despite the development of neuroscience and spectacular discoveries, the clear functions and the role of histamine are still not fully understood, especially in the context of the negative impact of prolonged stress exposure on the cognition. The purpose of this
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