C2755

Cortisone

synthetic, ≥95%, powder

• Sinónimos: 17α,21-Dihydroxy-4-pregnene-3,11,20-trione, 17α-Hydroxy-11-dehydrocorticosterone, 4-Pregnene-17α,21-diol-3,11,20-trione, Kendall’s Compound E, Reichstein’s Substance Fa
• Fórmula empírica (notación de Hill): C₂₁H₂₈O₅
• Número CAS: 53-06-5
• Peso molecular: 360.44
• NACRES: NA.77
• PubChem Substance ID: 24278304
• UNSPSC Code: 51111800
• EC Number: 200-162-4
• MDL number: MFCD00003610
• Beilstein/REAXYS Number: 1356062
• Assay: ≥95%
• Form: powder

Propiedades

• Nombre del producto: Cortisone, ≥95%
• biological source: synthetic
• Quality Segment: 200
• sterility: non-sterile
• assay: ≥95%
• form: powder
• technique(s): inhibition assay: suitable
• mp: 223-228 °C (dec.) (lit.)
• solubility: chloroform: methanol (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• shipped in: ambient
• storage temp.: room temp
• SMILES string: C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)CC(=O)[C@H]23
• InChI: 1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
• InChI key: MFYSYFVPBJMHGN-ZPOLXVRWSA-N
• Gene Information: human ... SERPINA6(866)

Descripción

Application

Cortisone has been used:

• to validate a 1β-HSD1 (11β-hydroxysteroid dehydrogenase type 1) inhibitor
• to study the sensitivity of erythropoietic and granulopoietic progenitor cells to cortisone
• in the determination of rates of cortisol oxidation by 11βHSD

Biochem/physiol Actions

Cortisone (11 dehydro 17 hydroxycortico-sterone) is an anti-inflammatory glucocorticoid that delays wound healing after surgeries. It postpones the healing process by affecting the appearance of inflammatory cells, ground substance, fibroblasts, collagen, regenerating capillaries, and epithelial migration. Glucocorticoids have anti-inflammatory, anti-allergic and immunosuppressive properties and are extensively used in treatment and therapy.

Cortisone is a glucocorticoid; a corticosterone analog that has approximately twice the anti-inflammatory potency as corticosterone but much lower Na²⁺ retention potency.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Información de seguridad

• pictograms: GHS08
• signalword: Warning
• hcodes: H361d
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)