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C2743
Cytochalasin B from Drechslera dematioidea
Ready Made Solution, 10 mg/mL in DMSO
Sinónimos:
Phomin
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Quality Segment
form
ready-to-use solution
concentration
10 mg/mL in DMSO
antibiotic activity spectrum
fungi
application(s)
advanced drug delivery
mode of action
cell membrane | interferes
storage temp.
−20°C
SMILES string
C[C@@H]1CCC[C@@H](O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O
InChI
1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
InChI key
GBOGMAARMMDZGR-TYHYBEHESA-N
Application
- to block cytokinesis, to obtain binucleated cells[4]
- as a specific glucose transporter inhibitor
- to inhibit glucose transport by class I and III GLUTs to determine the 50% inhibitory concentration (IC50) in HCMV-infected and mock-infected cells
Biochem/physiol Actions
Other Notes
1 of 1
Este artículo | |||
|---|---|---|---|
| mode of action cell membrane | interferes | mode of action enzyme | interferes | mode of action DNA synthesis | interferes | mode of action cell membrane | interferes |
| antibiotic activity spectrum fungi | antibiotic activity spectrum fungi | antibiotic activity spectrum fungi | antibiotic activity spectrum neoplastics |
| Quality Level 200 | Quality Level 300 | Quality Level 300 | Quality Level 200 |
| form ready-to-use solution | form ready-to-use solution | form powder | form ready-to-use solution |
| application(s) advanced drug delivery | application(s) advanced drug delivery | application(s) - | application(s) advanced drug delivery |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 4 Oral
Clase de almacenamiento
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 2
flash_point_f
185.0 °F - closed cup - Solvent
flash_point_c
85 °C - closed cup - Solvent
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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How does the storage temperature relate to shipping conditions?
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Is Product C2743, Cytochalasin B, cell culture grade?
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The product has been sterile filtered, but it has not been cell culture tested by Sigma.
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I have a solution of Product C2743, Cytochalasin B, in DMSO. Is the DMSO toxic to cultured cells?
1 answer-
At a low enough concentration, the DMSO should not hurt the cells. The final concentration of DMSO in the aqueous working medium typically should not exceed 0.1% because higher DMSO concentrations can adversely affect many cultured cells. Dilute the product in the appropriate aqueous medium to provide a physiologically acceptable final concentration.
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